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Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases

Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as bi...

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Detalles Bibliográficos
Autores principales: Dinica, Rodica Mihaela, Furdui, Bianca, Ghinea, Ioana Otilia, Bahrim, Gabriela, Bonte, Simon, Demeunynck, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640390/
https://www.ncbi.nlm.nih.gov/pubmed/23389089
http://dx.doi.org/10.3390/md11020431
Descripción
Sumario:Marine microorganisms are of considerable interest as a promising source of enzymes with unsuspected potentials as catalysts for chemical synthesis. We describe here an efficient method for one-pot indolizine synthesis that has been developed using lipase A and lipase B from Candida antarctica as biocatalysts. As showed by HPLC/MS analysis, the yield in indolizines was higher in the presence of the biocatalyst than in absence of enzyme. Lipase A, from Candida antarctica, showed high catalytic activity and selectivity for the cycloaddition reactions. When the reactions were performed under ultrasound irradiation, the Candida antarctica lipase catalyzed reactions yielded pure indolozines, in good yields and in very short time.