New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp

Six new casbane diterpenoids, named as sinularcasbanes A–F (1–6), along with six known analogues 7–12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the li...

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Detalles Bibliográficos
Autores principales: Yin, Jian, Zhao, Min, Ma, Minshan, Xu, Yuping, Xiang, Zheng, Cai, Yuepiao, Dong, Jianyong, Lei, Xinxiang, Huang, Kexin, Yan, Pengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640392/
https://www.ncbi.nlm.nih.gov/pubmed/23389091
http://dx.doi.org/10.3390/md11020455
Descripción
Sumario:Six new casbane diterpenoids, named as sinularcasbanes A–F (1–6), along with six known analogues 7–12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against selected cancer cell lines and the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages.

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