New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp

Six new casbane diterpenoids, named as sinularcasbanes A–F (1–6), along with six known analogues 7–12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the li...

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Autores principales: Yin, Jian, Zhao, Min, Ma, Minshan, Xu, Yuping, Xiang, Zheng, Cai, Yuepiao, Dong, Jianyong, Lei, Xinxiang, Huang, Kexin, Yan, Pengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640392/
https://www.ncbi.nlm.nih.gov/pubmed/23389091
http://dx.doi.org/10.3390/md11020455
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author Yin, Jian
Zhao, Min
Ma, Minshan
Xu, Yuping
Xiang, Zheng
Cai, Yuepiao
Dong, Jianyong
Lei, Xinxiang
Huang, Kexin
Yan, Pengcheng
author_facet Yin, Jian
Zhao, Min
Ma, Minshan
Xu, Yuping
Xiang, Zheng
Cai, Yuepiao
Dong, Jianyong
Lei, Xinxiang
Huang, Kexin
Yan, Pengcheng
author_sort Yin, Jian
collection PubMed
description Six new casbane diterpenoids, named as sinularcasbanes A–F (1–6), along with six known analogues 7–12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against selected cancer cell lines and the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages.
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spelling pubmed-36403922013-05-02 New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp Yin, Jian Zhao, Min Ma, Minshan Xu, Yuping Xiang, Zheng Cai, Yuepiao Dong, Jianyong Lei, Xinxiang Huang, Kexin Yan, Pengcheng Mar Drugs Article Six new casbane diterpenoids, named as sinularcasbanes A–F (1–6), along with six known analogues 7–12, were isolated from a South China Sea soft coral, Sinularia sp. The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against selected cancer cell lines and the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse peritoneal macrophages. MDPI 2013-02-06 /pmc/articles/PMC3640392/ /pubmed/23389091 http://dx.doi.org/10.3390/md11020455 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yin, Jian
Zhao, Min
Ma, Minshan
Xu, Yuping
Xiang, Zheng
Cai, Yuepiao
Dong, Jianyong
Lei, Xinxiang
Huang, Kexin
Yan, Pengcheng
New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp
title New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp
title_full New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp
title_fullStr New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp
title_full_unstemmed New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp
title_short New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp
title_sort new casbane diterpenoids from a south china sea soft coral, sinularia sp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640392/
https://www.ncbi.nlm.nih.gov/pubmed/23389091
http://dx.doi.org/10.3390/md11020455
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