Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis

The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of these receptors through evaluation of the Antxr kno...

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Detalles Bibliográficos
Autores principales: Reeves, Claire, Charles-Horvath, Pelisa, Kitajewski, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640537/
https://www.ncbi.nlm.nih.gov/pubmed/23389402
http://dx.doi.org/10.3390/toxins5020315
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author Reeves, Claire
Charles-Horvath, Pelisa
Kitajewski, Jan
author_facet Reeves, Claire
Charles-Horvath, Pelisa
Kitajewski, Jan
author_sort Reeves, Claire
collection PubMed
description The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of these receptors through evaluation of the Antxr knockout mouse phenotypes. Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication.
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spelling pubmed-36405372013-05-03 Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis Reeves, Claire Charles-Horvath, Pelisa Kitajewski, Jan Toxins (Basel) Review The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of these receptors through evaluation of the Antxr knockout mouse phenotypes. Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication. MDPI 2013-02-06 /pmc/articles/PMC3640537/ /pubmed/23389402 http://dx.doi.org/10.3390/toxins5020315 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Reeves, Claire
Charles-Horvath, Pelisa
Kitajewski, Jan
Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis
title Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis
title_full Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis
title_fullStr Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis
title_full_unstemmed Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis
title_short Studies in Mice Reveal a Role for Anthrax Toxin Receptors in Matrix Metalloproteinase Function and Extracellular Matrix Homeostasis
title_sort studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular matrix homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640537/
https://www.ncbi.nlm.nih.gov/pubmed/23389402
http://dx.doi.org/10.3390/toxins5020315
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AT kitajewskijan studiesinmicerevealaroleforanthraxtoxinreceptorsinmatrixmetalloproteinasefunctionandextracellularmatrixhomeostasis

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