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On The Role of Natural Killer Cells in Neurodegenerative Diseases
Natural killer (NK) cells exert important immunoregulatory functions by releasing several inflammatory molecules, such as IFN-γ and members of chemokines, which include CCL3/MIP-1α and CCL4/MIP-1β. These cells also express heptahelical receptors, which are coupled to heterotrimeric G proteins that g...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640540/ https://www.ncbi.nlm.nih.gov/pubmed/23430541 http://dx.doi.org/10.3390/toxins5020363 |
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author | Maghazachi, Azzam A. |
author_facet | Maghazachi, Azzam A. |
author_sort | Maghazachi, Azzam A. |
collection | PubMed |
description | Natural killer (NK) cells exert important immunoregulatory functions by releasing several inflammatory molecules, such as IFN-γ and members of chemokines, which include CCL3/MIP-1α and CCL4/MIP-1β. These cells also express heptahelical receptors, which are coupled to heterotrimeric G proteins that guide them into inflamed and injured tissues. NK cells have been shown to recognize and destroy transformed cells and virally-infected cells, but their roles in neurodegenerative diseases have not been examined in detail. In this review, I will summarize the effects of NK cells in two neurodegenerative diseases, namely multiple sclerosis and globoid cell leukodystrophy. It is hoped that the knowledge obtained from these diseases may facilitate building rational protocols for treating these and other neurodegenerative or autoimmune diseases using NK cells and drugs that activate them as therapeutic tools. |
format | Online Article Text |
id | pubmed-3640540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-36405402013-05-03 On The Role of Natural Killer Cells in Neurodegenerative Diseases Maghazachi, Azzam A. Toxins (Basel) Review Natural killer (NK) cells exert important immunoregulatory functions by releasing several inflammatory molecules, such as IFN-γ and members of chemokines, which include CCL3/MIP-1α and CCL4/MIP-1β. These cells also express heptahelical receptors, which are coupled to heterotrimeric G proteins that guide them into inflamed and injured tissues. NK cells have been shown to recognize and destroy transformed cells and virally-infected cells, but their roles in neurodegenerative diseases have not been examined in detail. In this review, I will summarize the effects of NK cells in two neurodegenerative diseases, namely multiple sclerosis and globoid cell leukodystrophy. It is hoped that the knowledge obtained from these diseases may facilitate building rational protocols for treating these and other neurodegenerative or autoimmune diseases using NK cells and drugs that activate them as therapeutic tools. MDPI 2013-02-19 /pmc/articles/PMC3640540/ /pubmed/23430541 http://dx.doi.org/10.3390/toxins5020363 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Maghazachi, Azzam A. On The Role of Natural Killer Cells in Neurodegenerative Diseases |
title | On The Role of Natural Killer Cells in Neurodegenerative Diseases |
title_full | On The Role of Natural Killer Cells in Neurodegenerative Diseases |
title_fullStr | On The Role of Natural Killer Cells in Neurodegenerative Diseases |
title_full_unstemmed | On The Role of Natural Killer Cells in Neurodegenerative Diseases |
title_short | On The Role of Natural Killer Cells in Neurodegenerative Diseases |
title_sort | on the role of natural killer cells in neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640540/ https://www.ncbi.nlm.nih.gov/pubmed/23430541 http://dx.doi.org/10.3390/toxins5020363 |
work_keys_str_mv | AT maghazachiazzama ontheroleofnaturalkillercellsinneurodegenerativediseases |