Cargando…

In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [(18)F]FEDAA1106

BACKGROUND: The activation of microglia, in general, and the upregulation of the translocator protein (18 kDa) (TSPO) system, in particular, are key features of neuroinflammation, of which the in vivo visualization and quantitative assessment are still challenging due to the lack of appropriate mole...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takano, Akihiro, Piehl, Fredrik, Hillert, Jan, Varrone, Andrea, Nag, Sangram, Gulyás, Balázs, Stenkrona, Per, Villemagne, Victor L, Rowe, Christopher C, Macdonell, Richard, Tawil, Nabil Al, Kucinski, Thomas, Zimmermann, Torsten, Schultze-Mosgau, Marcus, Thiele, Andrea, Hoffmann, Anja, Halldin, Christer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640965/ https://www.ncbi.nlm.nih.gov/pubmed/23618062 http://dx.doi.org/10.1186/2191-219X-3-30

Ejemplares similares

Test-retest reproducibility of [(11)C]-l-deprenyl-D(2) binding to MAO-B in the human brain
por: Arakawa, Ryosuke, et al.
Publicado: (2017)

PET Imaging of VMAT2 with the Novel Radioligand [(18)F]FE-DTBZ-d4 in Nonhuman Primates: Comparison with [(11)C]DTBZ and [(18)F]FE-DTBZ
por: Nag, Sangram, et al.
Publicado: (2021)

PET imaging of [(11)C]PBR28 in Parkinson’s disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding
por: Varnäs, Katarina, et al.
Publicado: (2018)

PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [(18)F]PF-06684511
por: Arakawa, Ryosuke, et al.
Publicado: (2020)

Venlafaxine ER Blocks the Norepinephrine Transporter in the Brain of Patients with Major Depressive Disorder: a PET Study Using [(18)F]FMeNER-D(2)
por: Arakawa, Ryosuke, et al.
Publicado: (2019)

Kinetic analysis and test-retest variability of the radioligand [(11)C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
por: Jučaite, Aurelija, et al.
Publicado: (2012)

Positron Emission Tomography studies with [(11)C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation
por: Tóth, Miklós, et al.
Publicado: (2015)

Guidelines to PET measurements of the target occupancy in the brain for drug development
por: Takano, Akihiro, et al.
Publicado: (2016)

Dual tracer tau PET imaging reveals different molecular targets for (11)C-THK5351 and (11)C-PBB3 in the Alzheimer brain
por: Chiotis, Konstantinos, et al.
Publicado: (2018)

PET Evaluation of the Novel F-18 Labeled Reversible Radioligand [(18)F]GEH200449 for Detection of Monoamine Oxidase-B in the Non-Human Primate Brain
por: Varnäs, Katarina, et al.
Publicado: (2023)

Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer’s disease and elderly controls after oral administration of sembragiline
por: Sturm, Stefan, et al.
Publicado: (2016)

ABC transporter-dependent brain uptake of the 5-HT(1B) receptor radioligand [(11)C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig
por: Tóth, Miklós, et al.
Publicado: (2014)

Serotonin 1B receptor density mapping of the human brainstem using positron emission tomography and autoradiography
por: Veldman, Emma R, et al.
Publicado: (2021)

D1-Dopamine Receptor Availability in First-Episode Neuroleptic Naive Psychosis Patients
por: Stenkrona, Per, et al.
Publicado: (2019)

Microsome Mediated in Vitro Metabolism: A Convenient Method for the Preparation of the PET Radioligand Metabolite [(18)F]FE-PE2I-OH for Translational Dopamine Transporter Imaging
por: Schou, Magnus, et al.
Publicado: (2023)

Effect of Food Intake on the Pharmacokinetics of the Selective Progesterone Receptor Modulator Vilaprisan: A Randomized Clinical Study in Healthy Postmenopausal Women
por: Schultze‐Mosgau, Marcus‐Hillert, et al.
Publicado: (2020)

Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [(11)C]PBR28 HRRT PET study
por: Tuisku, Jouni, et al.
Publicado: (2019)

[(18)F]FE-PE2I DAT correlates with Parkinson’s disease duration, stage, and rigidity/bradykinesia scores: a PET radioligand validation study
por: Kerstens, Vera S., et al.
Publicado: (2023)

Production of [(11)C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer
por: Mallapura, Hemantha, et al.
Publicado: (2022)

Revisiting the Logan plot to account for non-negligible blood volume in brain tissue
por: Schain, Martin, et al.
Publicado: (2017)

Synthesis, Biodistribution, and Radiation Dosimetry of a Novel mGluR5 Radioligand: (18)F-AZD9272
por: Nag, Sangram, et al.
Publicado: (2020)

Decreased 5‐HT(1A) binding in mild Alzheimer's disease—A positron emission tomography study
por: Mattsson, Patrik, et al.
Publicado: (2022)

High-resolution PET imaging reveals subtle impairment of the serotonin transporter in an early non-depressed Parkinson’s disease cohort
por: Fazio, Patrik, et al.
Publicado: (2020)

[(11)C]SCH23390 binding to the D(1)-dopamine receptor in the human brain—a comparison of manual and automated methods for image analysis
por: Stenkrona, Per, et al.
Publicado: (2018)

Quantification of the purinergic P2X(7) receptor with [(11)C]SMW139 improves through correction for brain-penetrating radiometabolites
por: Brumberg, Joachim, et al.
Publicado: (2022)

1106. Evaluation of Penetration of Cefiderocol into Cerebrospinal Fluid Using a Rat Meningitis Model
por: Takemura, Miki, et al.
Publicado: (2021)

Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study
por: Plavén-Sigray, Pontus, et al.
Publicado: (2018)

Synthesis and Autoradiography of Novel F-18 Labeled Reversible Radioligands for Detection of Monoamine Oxidase B
por: Nag, Sangram, et al.
Publicado: (2020)

Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies
por: Möller, Carsten, et al.
Publicado: (2018)

Pharmacokinetics and Safety of the Novel Selective Progesterone Receptor Modulator Vilaprisan in Participants With Renal Impairment
por: Schultze‐Mosgau, Marcus‐Hillert, et al.
Publicado: (2020)

Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview
por: Schultze-Mosgau, Marcus-Hillert, et al.
Publicado: (2021)

Extrapleural locating method in computed tomography-guided needle biopsies of 1,106 lung lesions
por: WEI, YUE-HUA, et al.
Publicado: (2015)

1106. Comparison of Diagnostic Power of Conventional Culture and Automated Blood Culture System with Pleural Fluid
por: Ho Lee, Young, et al.
Publicado: (2023)

Potential for imaging the high-affinity state of the 5-HT(1B) receptor: a comparison of three PET radioligands with differing intrinsic activity
por: Lindberg, Anton, et al.
Publicado: (2019)

Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease
por: Tournier, Benjamin B., et al.
Publicado: (2020)

Effect of hepatic impairment on the pharmacokinetics of vilaprisan: An open‐label, single‐dose, parallel‐group study
por: Chattopadhyay, Niladri, et al.
Publicado: (2019)

Quantification and reliability of [(11)C]VC - 002 binding to muscarinic acetylcholine receptors in the human lung — a test-retest PET study in control subjects
por: Cselényi, Zsolt, et al.
Publicado: (2020)

Characterization of a Novel M4 PAM PET Radioligand [11C]PF06885190 in Nonhuman Primates (NHP)
por: Nag, Sangram, et al.
Publicado: (2023)

Reliability of dopamine transporter PET measurements with [(18)F]FE-PE2I in patients with Parkinson’s disease
por: Kerstens, Vera S., et al.
Publicado: (2020)

Serotonin and Norepinephrine Transporter Occupancy of Tramadol in Nonhuman Primate Using Positron Emission Tomography
por: Arakawa, Ryosuke, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ml3ibtr6p4to0u8d6ugfjsmb1o