Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma

BACKGROUND: Expression of the constitutively activated mutant EGFR variant III (EGFRvIII), the most common mutation in glioblastoma multiforme (GBMs), has been clinically correlated with tumor proliferation, invasion, and angiogenesis. In this study, we examined the role of EGFRvIII on the tumor mic...

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Detalles Bibliográficos
Autores principales: Katanasaka, Yasufumi, Kodera, Yasuo, Kitamura, Yuka, Morimoto, Tatsuya, Tamura, Tomohide, Koizumi, Fumiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641008/
https://www.ncbi.nlm.nih.gov/pubmed/23617883
http://dx.doi.org/10.1186/1476-4598-12-31

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