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Construction and analysis of the protein-protein interaction network related to essential hypertension

BACKGROUND: Essential hypertension (EH) is a complex disease as a consequence of interaction between environmental factors and genetic background, but the pathogenesis of EH remains elusive. The emerging tools of network medicine offer a platform to explore a complex disease at system level. In this...

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Autores principales: Ran, Jihua, Li, Hui, Fu, Jianfeng, Liu, Ling, Xing, Yanchao, Li, Xiumei, Shen, Hongming, Chen, Yan, Jiang, Xiaofang, Li, Yan, Li, Huiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641020/
https://www.ncbi.nlm.nih.gov/pubmed/23587307
http://dx.doi.org/10.1186/1752-0509-7-32
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author Ran, Jihua
Li, Hui
Fu, Jianfeng
Liu, Ling
Xing, Yanchao
Li, Xiumei
Shen, Hongming
Chen, Yan
Jiang, Xiaofang
Li, Yan
Li, Huiwu
author_facet Ran, Jihua
Li, Hui
Fu, Jianfeng
Liu, Ling
Xing, Yanchao
Li, Xiumei
Shen, Hongming
Chen, Yan
Jiang, Xiaofang
Li, Yan
Li, Huiwu
author_sort Ran, Jihua
collection PubMed
description BACKGROUND: Essential hypertension (EH) is a complex disease as a consequence of interaction between environmental factors and genetic background, but the pathogenesis of EH remains elusive. The emerging tools of network medicine offer a platform to explore a complex disease at system level. In this study, we aimed to identify the key proteins and the biological regulatory pathways involving in EH and further to explore the molecular connectivities between these pathways by the topological analysis of the Protein-protein interaction (PPI) network. RESULT: The extended network including one giant network consisted of 535 nodes connected via 2572 edges and two separated small networks. 27 proteins with high BC and 28 proteins with large degree have been identified. NOS3 with highest BC and Closeness centrality located in the centre of the network. The backbone network derived from high BC proteins presents a clear and visual overview which shows all important regulatory pathways for blood pressure (BP) and the crosstalk between them. Finally, the robustness of NOS3 as central protein and accuracy of backbone were validated by 287 test networks. CONCLUSION: Our finding suggests that blood pressure variation is orchestrated by an integrated PPI network centered on NOS3.
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spelling pubmed-36410202013-05-02 Construction and analysis of the protein-protein interaction network related to essential hypertension Ran, Jihua Li, Hui Fu, Jianfeng Liu, Ling Xing, Yanchao Li, Xiumei Shen, Hongming Chen, Yan Jiang, Xiaofang Li, Yan Li, Huiwu BMC Syst Biol Research Article BACKGROUND: Essential hypertension (EH) is a complex disease as a consequence of interaction between environmental factors and genetic background, but the pathogenesis of EH remains elusive. The emerging tools of network medicine offer a platform to explore a complex disease at system level. In this study, we aimed to identify the key proteins and the biological regulatory pathways involving in EH and further to explore the molecular connectivities between these pathways by the topological analysis of the Protein-protein interaction (PPI) network. RESULT: The extended network including one giant network consisted of 535 nodes connected via 2572 edges and two separated small networks. 27 proteins with high BC and 28 proteins with large degree have been identified. NOS3 with highest BC and Closeness centrality located in the centre of the network. The backbone network derived from high BC proteins presents a clear and visual overview which shows all important regulatory pathways for blood pressure (BP) and the crosstalk between them. Finally, the robustness of NOS3 as central protein and accuracy of backbone were validated by 287 test networks. CONCLUSION: Our finding suggests that blood pressure variation is orchestrated by an integrated PPI network centered on NOS3. BioMed Central 2013-04-12 /pmc/articles/PMC3641020/ /pubmed/23587307 http://dx.doi.org/10.1186/1752-0509-7-32 Text en Copyright © 2013 Ran et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ran, Jihua
Li, Hui
Fu, Jianfeng
Liu, Ling
Xing, Yanchao
Li, Xiumei
Shen, Hongming
Chen, Yan
Jiang, Xiaofang
Li, Yan
Li, Huiwu
Construction and analysis of the protein-protein interaction network related to essential hypertension
title Construction and analysis of the protein-protein interaction network related to essential hypertension
title_full Construction and analysis of the protein-protein interaction network related to essential hypertension
title_fullStr Construction and analysis of the protein-protein interaction network related to essential hypertension
title_full_unstemmed Construction and analysis of the protein-protein interaction network related to essential hypertension
title_short Construction and analysis of the protein-protein interaction network related to essential hypertension
title_sort construction and analysis of the protein-protein interaction network related to essential hypertension
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641020/
https://www.ncbi.nlm.nih.gov/pubmed/23587307
http://dx.doi.org/10.1186/1752-0509-7-32
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