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Changes in Gene Expression Profiling of Apoptotic Genes in Neuroblastoma Cell Lines upon Retinoic Acid Treatment

To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers induced apoptosis and reduced cell density as a result of cell differentiation an...

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Detalles Bibliográficos
Autores principales: Celay, Jon, Blanco, Idoia, Lázcoz, Paula, Rotinen, Mirja, Castresana, Javier S., Encío, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641123/
https://www.ncbi.nlm.nih.gov/pubmed/23650528
http://dx.doi.org/10.1371/journal.pone.0062771