In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition

HDM2 binds to the p53 tumour suppressor and targets it for proteosomal degradation. Presently in clinical trials, the small molecule Nutlin-3A competitively binds to HDM2 and abrogates its repressive function. Using a novel in vitro selection methodology, we simulated the emergence of resistance by...

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Detalles Bibliográficos
Autores principales: Wei, Siau Jia, Joseph, Thomas, Sim, Adelene Y. L., Yurlova, Larisa, Zolghadr, Kourosh, Lane, David, Verma, Chandra, Ghadessy, Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641235/
https://www.ncbi.nlm.nih.gov/pubmed/23653682
http://dx.doi.org/10.1371/journal.pone.0062564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641235/
https://www.ncbi.nlm.nih.gov/pubmed/23653682
http://dx.doi.org/10.1371/journal.pone.0062564

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