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Potential for therapeutic manipulation of the UPR in disease

Increased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological processes as well as under pathological conditions. The UPR normally protects cells and re-establishes cellular homeostasis, but prolonged UPR ac...

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Detalles Bibliográficos
Autores principales: Park, Sang Won, Ozcan, Umut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641308/
https://www.ncbi.nlm.nih.gov/pubmed/23572207
http://dx.doi.org/10.1007/s00281-013-0370-z
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author Park, Sang Won
Ozcan, Umut
author_facet Park, Sang Won
Ozcan, Umut
author_sort Park, Sang Won
collection PubMed
description Increased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological processes as well as under pathological conditions. The UPR normally protects cells and re-establishes cellular homeostasis, but prolonged UPR activation can lead to the development of various pathologies. These features make the UPR signaling pathway an attractive target for the treatment of diseases whose pathogenesis is characterized by chronic activation of this pathway. Here, we focus on the molecular signaling pathways of the UPR and suggest possible ways to target this response for therapeutic purposes.
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spelling pubmed-36413082013-05-02 Potential for therapeutic manipulation of the UPR in disease Park, Sang Won Ozcan, Umut Semin Immunopathol Review Increased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological processes as well as under pathological conditions. The UPR normally protects cells and re-establishes cellular homeostasis, but prolonged UPR activation can lead to the development of various pathologies. These features make the UPR signaling pathway an attractive target for the treatment of diseases whose pathogenesis is characterized by chronic activation of this pathway. Here, we focus on the molecular signaling pathways of the UPR and suggest possible ways to target this response for therapeutic purposes. Springer-Verlag 2013-04-10 2013 /pmc/articles/PMC3641308/ /pubmed/23572207 http://dx.doi.org/10.1007/s00281-013-0370-z Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Park, Sang Won
Ozcan, Umut
Potential for therapeutic manipulation of the UPR in disease
title Potential for therapeutic manipulation of the UPR in disease
title_full Potential for therapeutic manipulation of the UPR in disease
title_fullStr Potential for therapeutic manipulation of the UPR in disease
title_full_unstemmed Potential for therapeutic manipulation of the UPR in disease
title_short Potential for therapeutic manipulation of the UPR in disease
title_sort potential for therapeutic manipulation of the upr in disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641308/
https://www.ncbi.nlm.nih.gov/pubmed/23572207
http://dx.doi.org/10.1007/s00281-013-0370-z
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