Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F

Owing to the prevalence of the JAK2V617F mutation in myeloproliferative neoplasms (MPNs), its constitutive activity, and ability to recapitulate the MPN phenotype in mouse models, JAK2V617F kinase is an attractive therapeutic target. We report the discovery and initial characterization of the orally...

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Detalles Bibliográficos
Autores principales: Ma, L, Clayton, J R, Walgren, R A, Zhao, B, Evans, R J, Smith, M C, Heinz-Taheny, K M, Kreklau, E L, Bloem, L, Pitou, C, Shen, W, Strelow, J M, Halstead, C, Rempala, M E, Parthasarathy, S, Gillig, J R, Heinz, L J, Pei, H, Wang, Y, Stancato, L F, Dowless, M S, Iversen, P W, Burkholder, T P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641321/
https://www.ncbi.nlm.nih.gov/pubmed/23584399
http://dx.doi.org/10.1038/bcj.2013.6

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