Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

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Sustained activation of neuronal N-methly D-aspartate (NMDA)-type glutamate receptors leads to excitotoxic cell death in stroke, trauma, and neurodegenerative disorders. Excitotoxic neuronal death results in part from superoxide produced by neuronal NADPH oxidase (NOX2), but how NMDA receptors are c...

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Detalles Bibliográficos
Autores principales: Brennan-Minnella, A M, Shen, Y, Swanson, R A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641334/
https://www.ncbi.nlm.nih.gov/pubmed/23559014
http://dx.doi.org/10.1038/cddis.2013.111

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