Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage

Runt-related transcription factor 2 (RUNX2) is the best known as an essential protein for osteoblast differentiation. In this study, we have found for the first time that RUNX2 acts as a negative regulator for p53 in response to DNA damage. On DNA damage mediated by adriamycin (ADR) exposure, p53 as...

Descripción completa

Detalles Bibliográficos
Autores principales: Ozaki, T, Wu, D, Sugimoto, H, Nagase, H, Nakagawara, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641350/
https://www.ncbi.nlm.nih.gov/pubmed/23618908
http://dx.doi.org/10.1038/cddis.2013.127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641350/
https://www.ncbi.nlm.nih.gov/pubmed/23618908
http://dx.doi.org/10.1038/cddis.2013.127

Ejemplares similares