Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

Oroxylin A is a major active component of the Chinese traditional medicinal plant Scutellaria baicalensis Georgi, which has been reported as a potential anticancer drug. We demonstrated that, Oroxylin A inhibited the glycolysis and the binding of hexokinase II (HK II) with mitochondria in human brea...

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Detalles Bibliográficos
Autores principales: Wei, L, Zhou, Y, Dai, Q, Qiao, C, Zhao, L, Hui, H, Lu, N, Guo, Q-L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641353/
https://www.ncbi.nlm.nih.gov/pubmed/23598413
http://dx.doi.org/10.1038/cddis.2013.131

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