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Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma
Oroxylin A is a major active component of the Chinese traditional medicinal plant Scutellaria baicalensis Georgi, which has been reported as a potential anticancer drug. We demonstrated that, Oroxylin A inhibited the glycolysis and the binding of hexokinase II (HK II) with mitochondria in human brea...
Autores principales: | Wei, L, Zhou, Y, Dai, Q, Qiao, C, Zhao, L, Hui, H, Lu, N, Guo, Q-L |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641353/ https://www.ncbi.nlm.nih.gov/pubmed/23598413 http://dx.doi.org/10.1038/cddis.2013.131 |
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