A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop

Despite initial and often dramatic responses of epidermal growth factor receptor (EGFR)-addicted lung tumors to the EGFR-specific tyrosine kinase inhibitors (TKIs), gefitinib and erlotinib, nearly all develop resistance and relapse. To explore novel mechanisms mediating acquired resistance, we emplo...

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Detalles Bibliográficos
Autores principales: Ware, K E, Hinz, T K, Kleczko, E, Singleton, K R, Marek, L A, Helfrich, B A, Cummings, C T, Graham, D K, Astling, D, Tan, A-C, Heasley, L E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641357/
https://www.ncbi.nlm.nih.gov/pubmed/23552882
http://dx.doi.org/10.1038/oncsis.2013.4

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