Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability

Hair cells at the base of the cochlea appear to be more susceptible to damage by the aminoglycoside gentamicin than those at the apex. However, the mechanism of base-to-apex gradient ototoxicity by gentamicin remains to be elucidated. We report here that gentamicin caused rodent cochlear hair cell d...

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Detalles Bibliográficos
Autores principales: Lee, Jeong-Han, Park, Channy, Kim, Se-Jin, Kim, Hyung-Jin, Oh, Gi-Su, Shen, AiHua, So, Hong-Seob, Park, Raekil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641395/
https://www.ncbi.nlm.nih.gov/pubmed/23470714
http://dx.doi.org/10.1038/emm.2013.25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641395/
https://www.ncbi.nlm.nih.gov/pubmed/23470714
http://dx.doi.org/10.1038/emm.2013.25

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