Cargando…

Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study

OBJECTIVE: To examine the relationship between acoustic characteristics of the first and second heart sounds (S1 and S2) and underlying cardiac structure and haemodynamics in patients with isolated pulmonary arterial hypertension (PAH) and controls. DESIGN: Prospective multicentre cohort study. SETT...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, William, Woldeyohannes, Maryam, Colman, Rebecca, Arand, Patti, Michaels, Andrew D, Parker, John D, Granton, John T, Mak, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641463/
https://www.ncbi.nlm.nih.gov/pubmed/23572199
http://dx.doi.org/10.1136/bmjopen-2013-002660
_version_ 1782268028648423424
author Chan, William
Woldeyohannes, Maryam
Colman, Rebecca
Arand, Patti
Michaels, Andrew D
Parker, John D
Granton, John T
Mak, Susanna
author_facet Chan, William
Woldeyohannes, Maryam
Colman, Rebecca
Arand, Patti
Michaels, Andrew D
Parker, John D
Granton, John T
Mak, Susanna
author_sort Chan, William
collection PubMed
description OBJECTIVE: To examine the relationship between acoustic characteristics of the first and second heart sounds (S1 and S2) and underlying cardiac structure and haemodynamics in patients with isolated pulmonary arterial hypertension (PAH) and controls. DESIGN: Prospective multicentre cohort study. SETTING: Tertiary referral and community hospitals. PARTICIPANTS: We prospectively evaluated 40 PAH patients undergoing right-heart catheterisation with contemporaneous digital acoustic cardiography (intensity and complexity) and two-dimensional transthoracic echocardiography. To normalise for differences in body habitus, acoustic variables were also expressed as a ratio (S2/S1). 130 participants (55 also had haemodynamic and/or echocardiographic assessment) without clinical or haemodynamic evidence of PAH or congestive heart failure acted as controls. RESULTS: Patients with PAH had higher mean pulmonary artery pressure (mPA; 40±13 vs 16±4 mm Hg, p<0.0001) and pulmonary vascular resistance (9±6 vs 1±1 Wood Units, p<0.0001) compared with controls, but cardiac index and mean pulmonary capillary wedge pressure were similar. More PAH patients had evidence of right ventricular (RV) dilation (50% vs 19%) and RV systolic dysfunction (41% vs 9%) in the moderate–severe range (all p<0.05). Compared with controls, the acoustic profiles of PAH patients were characterised by increased S2 complexity, S2/S1 complexity and S2/S1 intensity (all p<0.05). In the PAH cohort, S2 complexity was inversely related to S1 complexity. mPA was the only independent multivariate predictor of S2 complexity. The severity of RV enlargement and systolic impairment had reciprocal effects on the complexity of S2 (increased) and S1 (decreased). Decreased S1 complexity was also related to evidence of a small left ventricular cavity. CONCLUSIONS: Acoustic characteristics of both S1 and S2 are related to the severity of PAH and are associated with RV enlargement and systolic dysfunction. The reciprocal relationship between S2 and S1 complexity may also reflect the underlying ventricular interaction associated with PAH.
format Online
Article
Text
id pubmed-3641463
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-36414632013-05-07 Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study Chan, William Woldeyohannes, Maryam Colman, Rebecca Arand, Patti Michaels, Andrew D Parker, John D Granton, John T Mak, Susanna BMJ Open Cardiovascular Medicine OBJECTIVE: To examine the relationship between acoustic characteristics of the first and second heart sounds (S1 and S2) and underlying cardiac structure and haemodynamics in patients with isolated pulmonary arterial hypertension (PAH) and controls. DESIGN: Prospective multicentre cohort study. SETTING: Tertiary referral and community hospitals. PARTICIPANTS: We prospectively evaluated 40 PAH patients undergoing right-heart catheterisation with contemporaneous digital acoustic cardiography (intensity and complexity) and two-dimensional transthoracic echocardiography. To normalise for differences in body habitus, acoustic variables were also expressed as a ratio (S2/S1). 130 participants (55 also had haemodynamic and/or echocardiographic assessment) without clinical or haemodynamic evidence of PAH or congestive heart failure acted as controls. RESULTS: Patients with PAH had higher mean pulmonary artery pressure (mPA; 40±13 vs 16±4 mm Hg, p<0.0001) and pulmonary vascular resistance (9±6 vs 1±1 Wood Units, p<0.0001) compared with controls, but cardiac index and mean pulmonary capillary wedge pressure were similar. More PAH patients had evidence of right ventricular (RV) dilation (50% vs 19%) and RV systolic dysfunction (41% vs 9%) in the moderate–severe range (all p<0.05). Compared with controls, the acoustic profiles of PAH patients were characterised by increased S2 complexity, S2/S1 complexity and S2/S1 intensity (all p<0.05). In the PAH cohort, S2 complexity was inversely related to S1 complexity. mPA was the only independent multivariate predictor of S2 complexity. The severity of RV enlargement and systolic impairment had reciprocal effects on the complexity of S2 (increased) and S1 (decreased). Decreased S1 complexity was also related to evidence of a small left ventricular cavity. CONCLUSIONS: Acoustic characteristics of both S1 and S2 are related to the severity of PAH and are associated with RV enlargement and systolic dysfunction. The reciprocal relationship between S2 and S1 complexity may also reflect the underlying ventricular interaction associated with PAH. BMJ Publishing Group 2013-04-09 /pmc/articles/PMC3641463/ /pubmed/23572199 http://dx.doi.org/10.1136/bmjopen-2013-002660 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode
spellingShingle Cardiovascular Medicine
Chan, William
Woldeyohannes, Maryam
Colman, Rebecca
Arand, Patti
Michaels, Andrew D
Parker, John D
Granton, John T
Mak, Susanna
Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study
title Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study
title_full Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study
title_fullStr Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study
title_full_unstemmed Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study
title_short Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study
title_sort haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641463/
https://www.ncbi.nlm.nih.gov/pubmed/23572199
http://dx.doi.org/10.1136/bmjopen-2013-002660
work_keys_str_mv AT chanwilliam haemodynamicandstructuralcorrelatesofthefirstandsecondheartsoundsinpulmonaryarterialhypertensionanacousticcardiographycohortstudy
AT woldeyohannesmaryam haemodynamicandstructuralcorrelatesofthefirstandsecondheartsoundsinpulmonaryarterialhypertensionanacousticcardiographycohortstudy
AT colmanrebecca haemodynamicandstructuralcorrelatesofthefirstandsecondheartsoundsinpulmonaryarterialhypertensionanacousticcardiographycohortstudy
AT arandpatti haemodynamicandstructuralcorrelatesofthefirstandsecondheartsoundsinpulmonaryarterialhypertensionanacousticcardiographycohortstudy
AT michaelsandrewd haemodynamicandstructuralcorrelatesofthefirstandsecondheartsoundsinpulmonaryarterialhypertensionanacousticcardiographycohortstudy
AT parkerjohnd haemodynamicandstructuralcorrelatesofthefirstandsecondheartsoundsinpulmonaryarterialhypertensionanacousticcardiographycohortstudy
AT grantonjohnt haemodynamicandstructuralcorrelatesofthefirstandsecondheartsoundsinpulmonaryarterialhypertensionanacousticcardiographycohortstudy
AT maksusanna haemodynamicandstructuralcorrelatesofthefirstandsecondheartsoundsinpulmonaryarterialhypertensionanacousticcardiographycohortstudy