Cargando…

Updating clinical endpoint definitions

The 6-Minute Walk Distance (6-MWD) has been the most utilized endpoint for judging the efficacy of pulmonary arterial hypertension (PAH) therapy in clinical trials conducted over the past two decades. Despite its simplicity, widespread use in recent trials and overall prognostic value, the 6-MWD has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hassoun, Paul M., Nikkho, Sylvia, Rosenzweig, Erika B., Moreschi, Gail, Lawrence, John, Teeter, John, Meier, Christian, Ghofrani, Ardeshir H., Minai, Omar, Rinaldi, Paula, Michelakis, Evangelos, Oudiz, Ronald J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2013
Materias:	Pulmonary Hypertension–Academic Research Consortium: Clinical Endpoint Definitions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641732/ https://www.ncbi.nlm.nih.gov/pubmed/23662199 http://dx.doi.org/10.4103/2045-8932.109920

Ejemplares similares

The Role of Noninvasive Endpoints in Predicting Long-Term Outcomes in Pulmonary Arterial Hypertension
por: Wronski, Samantha L., et al.
Publicado: (2019)

The pulmonary hypertension academic research consortium
por: Rich, Stuart
Publicado: (2013)

Clinical trials in pulmonary hypertension: Time for a consortium
por: Newman, John H., et al.
Publicado: (2013)

Consensus Paper—ICIS Expert Meeting Basel 2009 treatment milestones in immune thrombocytopenia
por: Tamary, Hannah, et al.
Publicado: (2010)

Clinical trials in neonates and children: Report of the pulmonary hypertension academic research consortium pediatric advisory committee
por: Adatia, Ian, et al.
Publicado: (2013)

Real-World Switching to Riociguat: Management and Practicalities in Patients with PAH and CTEPH
por: Gall, Henning, et al.
Publicado: (2018)

Initial Riociguat Monotherapy and Transition from Sildenafil to Riociguat in Patients with Idiopathic Pulmonary Arterial Hypertension: Influence on Right Heart Remodeling and Right Ventricular–Pulmonary Arterial Coupling
por: Taran, Irina N., et al.
Publicado: (2018)

Pulmonary Hypertension in Heart Failure Patients
por: Rao, Sriram D, et al.
Publicado: (2020)

Can a New Scoring System Improve Prediction of Pulmonary Hypertension in Newly Recognised Interstitial Lung Diseases?
por: Sobiecka, Małgorzata, et al.
Publicado: (2020)

Identifying Patients with Group 3 Pulmonary Hypertension Associated with COPD or ILD Using an Administrative Claims Database
por: Heresi, Gustavo A., et al.
Publicado: (2022)

Advancing clinical trial design in pulmonary hypertension
por: Grieve, Andy P., et al.
Publicado: (2013)

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
por: Middeldorp, Christel M., et al.
Publicado: (2019)

Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension
por: Morrell, Nicholas W., et al.
Publicado: (2013)

Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo‐controlled multicentre trial
por: Cooper, Trond J., et al.
Publicado: (2022)

The LifeCycle Project-EU Child Cohort Network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
por: Jaddoe, Vincent W. V., et al.
Publicado: (2020)

Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium
por: Chibnik, Lori B., et al.
Publicado: (2017)

Scientific Integrity Principles and Best Practices: Recommendations from a Scientific Integrity Consortium
por: Kretser, Alison, et al.
Publicado: (2019)

Hemodynamic, Functional, and Clinical Responses to Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension of Different Causes: Phase II Results From the Pulmonary Artery Denervation-1 Study
por: Chen, Shao-Liang, et al.
Publicado: (2015)

Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension
por: Rothman, Alexander M.K., et al.
Publicado: (2015)

Epidemiology of pulmonary hypertension in the elderly
por: Örem, Cihan
Publicado: (2017)

How to select the appropriate candidate of pulmonary arterial hypertension: specific therapy in elderly patients with pulmonary hypertension
por: Yaylali, Yalin Tolga
Publicado: (2017)

Clinical and hemodynamic profiles of elderly patients with pulmonary arterial hypertension: a single center, prospective study
por: Ozpelit, Ebru, et al.
Publicado: (2017)

Which prognostic factors should be used in pulmonary arterial hypertension in elderly patients?
por: Akdeniz, Bahri, et al.
Publicado: (2017)

The combination of amlodipine/valsartan 5/160 mg produces less peripheral oedema than amlodipine 10 mg in hypertensive patients not adequately controlled with amlodipine 5 mg
por: Schrader, J, et al.
Publicado: (2009)

Endothelial Dysfunction in Diabetes: The role of reparatory mechanisms
por: Avogaro, Angelo, et al.
Publicado: (2011)

Endothelial Factors and Diabetic Nephropathy
por: Karalliedde, Janaka, et al.
Publicado: (2011)

Benefits of Tight Blood Pressure Control in Diabetic Patients With Hypertension: Importance of early and sustained implementation of effective treatment strategies
por: Parati, Gianfranco, et al.
Publicado: (2011)

Antihypertensive Treatment and Blood Pressure in Diabetic and Nondiabetic Patients: The lower, the better?
por: Mancia, Giuseppe, et al.
Publicado: (2011)

Blood Pressure: The Lower, the Better: The con side
por: Grossman, Ehud
Publicado: (2011)

Diuretic Treatment of Hypertension
por: Grossman, Ehud, et al.
Publicado: (2011)

RAS Blockade for Every Diabetic Patient: Pro and Con
por: Ruilope, Luis M., et al.
Publicado: (2011)

Monitoring Kidney Function and Albuminuria in Patients With Diabetes
por: Lambers Heerspink, Hiddo J., et al.
Publicado: (2011)

Limitations and Future Treatment Options in Type 2 Diabetes With Renal Impairment
por: Ritz, Eberhard
Publicado: (2011)

Individualization of Antihypertensive Drug Treatment
por: Mancia, Giuseppe, et al.
Publicado: (2013)

Intolerance to Statins: Mechanisms and Management
por: Bitzur, Rafael, et al.
Publicado: (2013)

Prognostic Value of Blood Pressure Variability and Average Blood Pressure Levels in Patients With Hypertension and Diabetes
por: Parati, Gianfranco, et al.
Publicado: (2013)

Ambulatory Blood Pressure Monitoring in the Diagnosis and Management of Hypertension
por: Grossman, Ehud
Publicado: (2013)

Familial history of hypertension as a predictor of increased arterial stiffness in normotensive offspring
por: Youssef, Ghada, et al.
Publicado: (2017)

Use of machine-learning algorithms to determine features of systolic blood pressure variability that predict poor outcomes in hypertensive patients
por: Lacson, Ronilda C, et al.
Publicado: (2018)

The Role of Nocturnal Blood Pressure and Sleep Quality in Hypertension Management
por: Cappuccio, Francesco P
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_f36gs758o67ec70u6jbci6l3so