Advancing clinical trial design in pulmonary hypertension

In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consid...

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Autores principales: Grieve, Andy P., Chow, Shien-Chung, Curram, John, Dawe, Stephen, Harnisch, Lutz O., Henig, Noreen R., Hung, Hsien Ming J., Ivy, D. Dunbar, Kawut, Steven M., Rahbar, Mohammad H., Xiao, Shen, Wilkins, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2013
Materias:
Pulmonary Hypertension–Academic Research Consortium: Novel Clinical Trial Designs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641733/
https://www.ncbi.nlm.nih.gov/pubmed/23662200
http://dx.doi.org/10.4103/2045-8932.109933
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author Grieve, Andy P.
Chow, Shien-Chung
Curram, John
Dawe, Stephen
Harnisch, Lutz O.
Henig, Noreen R.
Hung, Hsien Ming J.
Ivy, D. Dunbar
Kawut, Steven M.
Rahbar, Mohammad H.
Xiao, Shen
Wilkins, Martin R.
author_facet Grieve, Andy P.
Chow, Shien-Chung
Curram, John
Dawe, Stephen
Harnisch, Lutz O.
Henig, Noreen R.
Hung, Hsien Ming J.
Ivy, D. Dunbar
Kawut, Steven M.
Rahbar, Mohammad H.
Xiao, Shen
Wilkins, Martin R.
author_sort Grieve, Andy P.
collection PubMed
description In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clinical trial designs in pulmonary hypertension and here discusses their merits, limitations and challenges to implementation of novel approaches.
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spelling pubmed-36417332013-05-09 Advancing clinical trial design in pulmonary hypertension Grieve, Andy P. Chow, Shien-Chung Curram, John Dawe, Stephen Harnisch, Lutz O. Henig, Noreen R. Hung, Hsien Ming J. Ivy, D. Dunbar Kawut, Steven M. Rahbar, Mohammad H. Xiao, Shen Wilkins, Martin R. Pulm Circ Pulmonary Hypertension–Academic Research Consortium: Novel Clinical Trial Designs In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clinical trial designs in pulmonary hypertension and here discusses their merits, limitations and challenges to implementation of novel approaches. Medknow Publications 2013 /pmc/articles/PMC3641733/ /pubmed/23662200 http://dx.doi.org/10.4103/2045-8932.109933 Text en Copyright: © Pulmonary Circulation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pulmonary Hypertension–Academic Research Consortium: Novel Clinical Trial Designs
Grieve, Andy P.
Chow, Shien-Chung
Curram, John
Dawe, Stephen
Harnisch, Lutz O.
Henig, Noreen R.
Hung, Hsien Ming J.
Ivy, D. Dunbar
Kawut, Steven M.
Rahbar, Mohammad H.
Xiao, Shen
Wilkins, Martin R.
Advancing clinical trial design in pulmonary hypertension
title Advancing clinical trial design in pulmonary hypertension
title_full Advancing clinical trial design in pulmonary hypertension
title_fullStr Advancing clinical trial design in pulmonary hypertension
title_full_unstemmed Advancing clinical trial design in pulmonary hypertension
title_short Advancing clinical trial design in pulmonary hypertension
title_sort advancing clinical trial design in pulmonary hypertension
topic Pulmonary Hypertension–Academic Research Consortium: Novel Clinical Trial Designs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641733/
https://www.ncbi.nlm.nih.gov/pubmed/23662200
http://dx.doi.org/10.4103/2045-8932.109933
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