Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

The PARKIN (PARK2) ubiquitin ligase and its regulatory kinase PINK1 (PARK6), often mutated in familial early onset Parkinson’s Disease (PD), play central roles in mitochondrial homeostasis and mitophagy.(1–3) While PARKIN is recruited to the mitochondrial outer membrane (MOM) upon depolarization via...

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Detalles Bibliográficos
Autores principales: Sarraf, Shireen A., Raman, Malavika, Guarani-Pereira, Virginia, Sowa, Mathew E., Huttlin, Edward L., Gygi, Steven P., Harper, J. Wade
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641819/
https://www.ncbi.nlm.nih.gov/pubmed/23503661
http://dx.doi.org/10.1038/nature12043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641819/
https://www.ncbi.nlm.nih.gov/pubmed/23503661
http://dx.doi.org/10.1038/nature12043

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