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Chromatographic immunoassays for Helicobacter pylori detection – are they reliable in Mali, West Africa?
INTRODUCTION: Gastrointestinal diseases are major reasons for morbidity in Mali. As Helicobacter pylori is known to play a major role in gastritis and gastric ulcer we wanted to find a simple method for detection. METHODS: Twenty-nine volunteers with confirmed gastric ulcer by gastroscopy and 59 ran...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641924/ https://www.ncbi.nlm.nih.gov/pubmed/23646208 http://dx.doi.org/10.11604/pamj.2013.14.72.2131 |
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author | Austarheim, Ingvild Inngjerdingen, Kari Tvete Paulsen, Berit Smestad Togola, Adiaratou Diakité, Chiaka Diallo, Drissa |
author_facet | Austarheim, Ingvild Inngjerdingen, Kari Tvete Paulsen, Berit Smestad Togola, Adiaratou Diakité, Chiaka Diallo, Drissa |
author_sort | Austarheim, Ingvild |
collection | PubMed |
description | INTRODUCTION: Gastrointestinal diseases are major reasons for morbidity in Mali. As Helicobacter pylori is known to play a major role in gastritis and gastric ulcer we wanted to find a simple method for detection. METHODS: Twenty-nine volunteers with confirmed gastric ulcer by gastroscopy and 59 randomly selected volunteers were diagnosed by using the rapid serological test Clearview(®) H. Pylori. The ImmunoCard STAT!(®) HpSA(®)test was applied on stool from 65 volunteers seeking help for gastrointestinal related ailments. RESULTS: A Helicobacter pylori prevalence of 21% was found among the individuals with confirmed gastric ulcer, 44% among the randomly selected volunteers and 14% in individuals with gastrointestinal related ailments. CONCLUSION: According to what is already known about the aetiology of gastric ailments and the prevalence of Helicobacter pylori in neighboring countries, the infection rates in our study appear strikingly low. This might indicate that Clearview(®) H. Pylori and ImmunoCard STAT!(®) HpSA(®) have low sensitivities in the populations studied. Strain variability of H. Pylori may be an explanation. The tests need to be properly evaluated in Mali before they can be relied upon as diagnostic tools. |
format | Online Article Text |
id | pubmed-3641924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-36419242013-05-03 Chromatographic immunoassays for Helicobacter pylori detection – are they reliable in Mali, West Africa? Austarheim, Ingvild Inngjerdingen, Kari Tvete Paulsen, Berit Smestad Togola, Adiaratou Diakité, Chiaka Diallo, Drissa Pan Afr Med J Research INTRODUCTION: Gastrointestinal diseases are major reasons for morbidity in Mali. As Helicobacter pylori is known to play a major role in gastritis and gastric ulcer we wanted to find a simple method for detection. METHODS: Twenty-nine volunteers with confirmed gastric ulcer by gastroscopy and 59 randomly selected volunteers were diagnosed by using the rapid serological test Clearview(®) H. Pylori. The ImmunoCard STAT!(®) HpSA(®)test was applied on stool from 65 volunteers seeking help for gastrointestinal related ailments. RESULTS: A Helicobacter pylori prevalence of 21% was found among the individuals with confirmed gastric ulcer, 44% among the randomly selected volunteers and 14% in individuals with gastrointestinal related ailments. CONCLUSION: According to what is already known about the aetiology of gastric ailments and the prevalence of Helicobacter pylori in neighboring countries, the infection rates in our study appear strikingly low. This might indicate that Clearview(®) H. Pylori and ImmunoCard STAT!(®) HpSA(®) have low sensitivities in the populations studied. Strain variability of H. Pylori may be an explanation. The tests need to be properly evaluated in Mali before they can be relied upon as diagnostic tools. The African Field Epidemiology Network 2013-02-20 /pmc/articles/PMC3641924/ /pubmed/23646208 http://dx.doi.org/10.11604/pamj.2013.14.72.2131 Text en © Ingvild Austarheim et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Austarheim, Ingvild Inngjerdingen, Kari Tvete Paulsen, Berit Smestad Togola, Adiaratou Diakité, Chiaka Diallo, Drissa Chromatographic immunoassays for Helicobacter pylori detection – are they reliable in Mali, West Africa? |
title | Chromatographic immunoassays for Helicobacter pylori detection – are they reliable in Mali, West Africa? |
title_full | Chromatographic immunoassays for Helicobacter pylori detection – are they reliable in Mali, West Africa? |
title_fullStr | Chromatographic immunoassays for Helicobacter pylori detection – are they reliable in Mali, West Africa? |
title_full_unstemmed | Chromatographic immunoassays for Helicobacter pylori detection – are they reliable in Mali, West Africa? |
title_short | Chromatographic immunoassays for Helicobacter pylori detection – are they reliable in Mali, West Africa? |
title_sort | chromatographic immunoassays for helicobacter pylori detection – are they reliable in mali, west africa? |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641924/ https://www.ncbi.nlm.nih.gov/pubmed/23646208 http://dx.doi.org/10.11604/pamj.2013.14.72.2131 |
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