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Determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma
BACKGROUND: The purpose of this study was to determine the α/β ratio for normal liver with hepatitis by analyzing the toxicity data from patients with unresectable hepatocellular carcinoma treated with helical tomotherapy. METHODS: Between March 2006 and February 2012, 98 patients were eligible for...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641977/ https://www.ncbi.nlm.nih.gov/pubmed/23497395 http://dx.doi.org/10.1186/1748-717X-8-61 |
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author | Son, Seok Hyun Jang, Hong Seok Lee, Hyochun Choi, Byung Ock Kang, Young Nam Jang, Jeong Won Yoon, Seung Kew Kay, Chul Seung |
author_facet | Son, Seok Hyun Jang, Hong Seok Lee, Hyochun Choi, Byung Ock Kang, Young Nam Jang, Jeong Won Yoon, Seung Kew Kay, Chul Seung |
author_sort | Son, Seok Hyun |
collection | PubMed |
description | BACKGROUND: The purpose of this study was to determine the α/β ratio for normal liver with hepatitis by analyzing the toxicity data from patients with unresectable hepatocellular carcinoma treated with helical tomotherapy. METHODS: Between March 2006 and February 2012, 98 patients were eligible for this study. 66 patients received 45–50 Gy in 4.5-5 Gy fractions (Group A) and 32 patients received 36–60 Gy in 2.5-3 Gy fractions (Group B). Radiation-induced hepatic toxicity was defined as an increase of at least 2 points in the Child-Pugh score within 4 months of completing helical tomotherapy. We attempted to find the statistically significant parameters in the 2 groups using α/β ratios of 2, 4, 6, 8, or 10, and compared the estimated probability curves of each significant parameter. We hypothesized that the α/β ratio associated with the best matches for the curves between the 2 groups would be equivalent to the α/β ratio for the normal liver. RESULTS: When using an α/β ratio of 2 or 4, different parameters were found to be statistically significant in a multivariate analysis (Group A: V(BED30) for α/β ratio = 2 and V(BED25) for α/β ratio = 4, Group B: V(BED25) for α/β ratio = 2 and V(BED20) for α/β ratio = 4). When using an α/β ratio of 6, 8, or 10, V(BED20) was found to be a statistically significant parameter in both groups. Comparison of the estimated probability curve of each significant parameter between the groups revealed that an α/β ratio of 8 resulted in the best matches. CONCLUSIONS: We suggest that the α/β ratio of the normal liver with hepatitis is 8. We hope that previously reported parameters and their values can be effectively used in different fractionation schemes by calculating the biologically effective dose using an α/β ratio of 8. |
format | Online Article Text |
id | pubmed-3641977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36419772013-05-03 Determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma Son, Seok Hyun Jang, Hong Seok Lee, Hyochun Choi, Byung Ock Kang, Young Nam Jang, Jeong Won Yoon, Seung Kew Kay, Chul Seung Radiat Oncol Research BACKGROUND: The purpose of this study was to determine the α/β ratio for normal liver with hepatitis by analyzing the toxicity data from patients with unresectable hepatocellular carcinoma treated with helical tomotherapy. METHODS: Between March 2006 and February 2012, 98 patients were eligible for this study. 66 patients received 45–50 Gy in 4.5-5 Gy fractions (Group A) and 32 patients received 36–60 Gy in 2.5-3 Gy fractions (Group B). Radiation-induced hepatic toxicity was defined as an increase of at least 2 points in the Child-Pugh score within 4 months of completing helical tomotherapy. We attempted to find the statistically significant parameters in the 2 groups using α/β ratios of 2, 4, 6, 8, or 10, and compared the estimated probability curves of each significant parameter. We hypothesized that the α/β ratio associated with the best matches for the curves between the 2 groups would be equivalent to the α/β ratio for the normal liver. RESULTS: When using an α/β ratio of 2 or 4, different parameters were found to be statistically significant in a multivariate analysis (Group A: V(BED30) for α/β ratio = 2 and V(BED25) for α/β ratio = 4, Group B: V(BED25) for α/β ratio = 2 and V(BED20) for α/β ratio = 4). When using an α/β ratio of 6, 8, or 10, V(BED20) was found to be a statistically significant parameter in both groups. Comparison of the estimated probability curve of each significant parameter between the groups revealed that an α/β ratio of 8 resulted in the best matches. CONCLUSIONS: We suggest that the α/β ratio of the normal liver with hepatitis is 8. We hope that previously reported parameters and their values can be effectively used in different fractionation schemes by calculating the biologically effective dose using an α/β ratio of 8. BioMed Central 2013-03-15 /pmc/articles/PMC3641977/ /pubmed/23497395 http://dx.doi.org/10.1186/1748-717X-8-61 Text en Copyright © 2013 Son et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Son, Seok Hyun Jang, Hong Seok Lee, Hyochun Choi, Byung Ock Kang, Young Nam Jang, Jeong Won Yoon, Seung Kew Kay, Chul Seung Determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma |
title | Determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma |
title_full | Determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma |
title_fullStr | Determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma |
title_full_unstemmed | Determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma |
title_short | Determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma |
title_sort | determination of the α/β ratio for the normal liver on the basis of radiation-induced hepatic toxicities in patients with hepatocellular carcinoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641977/ https://www.ncbi.nlm.nih.gov/pubmed/23497395 http://dx.doi.org/10.1186/1748-717X-8-61 |
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