DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4(+) T Cells Infected with HIV

Productive HIV infection of CD4(+) T cells leads to a caspase-independent cell death pathway associated with lysosomal membrane permeabilization (LMP) and cathepsin release, resulting in mitochondrial outer membrane permeabilization (MOMP). Herein, we demonstrate that HIV infection induces damage-re...

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Detalles Bibliográficos
Autores principales: Laforge, Mireille, Limou, Sophie, Harper, Francis, Casartelli, Nicoletta, Rodrigues, Vasco, Silvestre, Ricardo, Haloui, Houda, Zagury, Jean-Francois, Senik, Anna, Estaquier, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642063/
https://www.ncbi.nlm.nih.gov/pubmed/23658518
http://dx.doi.org/10.1371/journal.ppat.1003328

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