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Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4(+) T Lymphocytes

The HIV transactivator protein, Tat, enhances HIV transcription by recruiting P-TEFb from the inactive 7SK snRNP complex and directing it to proviral elongation complexes. To test the hypothesis that T-cell receptor (TCR) signaling induces critical post-translational modifications leading to enhance...

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Detalles Bibliográficos
Autores principales:	Mbonye, Uri R., Gokulrangan, Giridharan, Datt, Manish, Dobrowolski, Curtis, Cooper, Maxwell, Chance, Mark R., Karn, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642088/ https://www.ncbi.nlm.nih.gov/pubmed/23658523 http://dx.doi.org/10.1371/journal.ppat.1003338

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