The Novel Ubiquitin Ligase Complex, SCF(Fbxw4), Interacts with the COP9 Signalosome in an F-Box Dependent Manner, Is Mutated, Lost and Under-Expressed in Human Cancers

Identification of novel proteins that can potentially contribute to carcinogenesis is a requisite venture. Herein, we report the first biochemical characterization of the novel F-box and WD40 containing protein, FBXW4. We have identified interacting protein partners and demonstrated that FBXW4 is pa...

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Detalles Bibliográficos
Autores principales: Lockwood, William W., Chandel, Sahiba K., Stewart, Greg L., Erdjument-Bromage, Hediye, Beverly, Levi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642104/
https://www.ncbi.nlm.nih.gov/pubmed/23658844
http://dx.doi.org/10.1371/journal.pone.0063610

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