The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes

Hsp90 is essential for maintaining the activity of numerous signaling factors, and plays a key role in cellular signal transduction networks. 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is an ansamycin antibiotic that binds to Hsp90 and inhibits its function. HaCaT human keratinocytes were used...

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Detalles Bibliográficos
Autores principales: Miyoshi, Sadanori, Yamazaki, Shota, Uchiumi, Asato, Katagata, Yohtaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642114/
https://www.ncbi.nlm.nih.gov/pubmed/23650580
http://dx.doi.org/10.1016/j.fob.2012.03.002
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author Miyoshi, Sadanori
Yamazaki, Shota
Uchiumi, Asato
Katagata, Yohtaro
author_facet Miyoshi, Sadanori
Yamazaki, Shota
Uchiumi, Asato
Katagata, Yohtaro
author_sort Miyoshi, Sadanori
collection PubMed
description Hsp90 is essential for maintaining the activity of numerous signaling factors, and plays a key role in cellular signal transduction networks. 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is an ansamycin antibiotic that binds to Hsp90 and inhibits its function. HaCaT human keratinocytes were used to investigate the cellular and molecular functions of Hsp90 in keratinocyte differentiation. Inhibition of Hsp90 by 17-AAG leads to downregulation of the differentiation markers cytokeratin 1 and cytokeratin 10 at the protein and mRNA levels.
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spelling pubmed-36421142013-05-06 The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes Miyoshi, Sadanori Yamazaki, Shota Uchiumi, Asato Katagata, Yohtaro FEBS Open Bio Article Hsp90 is essential for maintaining the activity of numerous signaling factors, and plays a key role in cellular signal transduction networks. 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is an ansamycin antibiotic that binds to Hsp90 and inhibits its function. HaCaT human keratinocytes were used to investigate the cellular and molecular functions of Hsp90 in keratinocyte differentiation. Inhibition of Hsp90 by 17-AAG leads to downregulation of the differentiation markers cytokeratin 1 and cytokeratin 10 at the protein and mRNA levels. Elsevier 2012-03-25 /pmc/articles/PMC3642114/ /pubmed/23650580 http://dx.doi.org/10.1016/j.fob.2012.03.002 Text en © 2012 Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non- commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Miyoshi, Sadanori
Yamazaki, Shota
Uchiumi, Asato
Katagata, Yohtaro
The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes
title The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes
title_full The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes
title_fullStr The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes
title_full_unstemmed The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes
title_short The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes
title_sort hsp90 inhibitor 17-aag represses calcium-induced cytokeratin 1 and 10 expression in hacat keratinocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642114/
https://www.ncbi.nlm.nih.gov/pubmed/23650580
http://dx.doi.org/10.1016/j.fob.2012.03.002
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