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Amino acid determinants conferring stable sialidase activity at low pH for H5N1 influenza A virus neuraminidase

Avian influenza A viruses (IAVs) and human 1918, 1957, and 1968 pandemic IAVs all have neuraminidases (NAs) that are stable at low pH sialidase activity, yet most human epidemic IAVs do not. We examined the pH stability of H5N1 highly pathogenic avian IAV (HPAI) NAs and identified amino acids respon...

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Detalles Bibliográficos
Autores principales:	Takahashi, Tadanobu, Nidom, Chairul A., Quynh Le, Mai thi, Suzuki, Takashi, Kawaoka, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642167/ https://www.ncbi.nlm.nih.gov/pubmed/23650608 http://dx.doi.org/10.1016/j.fob.2012.08.007

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