The cytoplasmic tail of heparin-binding EGF-like growth factor regulates bidirectional intracellular trafficking between the plasma membrane and ER

Heparin-binding epidermal growth factor (EGF)- like growth factor (HB-EGF) is synthesized in the ER, transported along the exocytic pathway, and expressed on the plasma membrane as a type I transmembrane protein. Upon extracellular stimulation, HB-EGF, either proHB-EGF or the shed form HB-EGF-CTF, u...

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Detalles Bibliográficos
Autores principales: Hieda, Miki, Koizumi, Michiko, Higashi, Chiduru, Tachibana, Taro, Taguchi, Tomohiko, Higashiyama, Shigeki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642169/
https://www.ncbi.nlm.nih.gov/pubmed/23650612
http://dx.doi.org/10.1016/j.fob.2012.09.002

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