Nicotinic Acid Receptor GPR109A Is Down-Regulated in Human Macrophage-Derived Foam Cells

Nicotinic acid (NA) regresses atherosclerosis in human imaging studies and reduces atherosclerosis in mice, mediated by myeloid cells, independent of lipoproteins. Since GPR109A is expressed by human monocytes, we hypothesized that NA may drive cholesterol efflux from foam cells. In THP-1 cells NA s...

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Detalles Bibliográficos
Autores principales: Chai, Joshua T., Digby, Janet E., Ruparelia, Neil, Jefferson, Andrew, Handa, Ashok, Choudhury, Robin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642175/
https://www.ncbi.nlm.nih.gov/pubmed/23658787
http://dx.doi.org/10.1371/journal.pone.0062934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642175/
https://www.ncbi.nlm.nih.gov/pubmed/23658787
http://dx.doi.org/10.1371/journal.pone.0062934

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