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Mitochondrial Ca(2+) Uptake from Plasma Membrane Cav3.2 Protein Channels Contributes to Ischemic Toxicity in PC12 Cells

T-type Ca(2+) channel inhibitors protect hippocampal CA1 neurons from delayed death after global ischemia in rats, suggesting that Cav3.1, Cav3.2, or Cav3.3 channels generate cytotoxic Ca(2+) elevations during anoxia. To test this hypothesis, we measured the Ca(2+) concentration changes evoked by ox...

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Detalles Bibliográficos
Autores principales:	Gouriou, Yves, Bijlenga, Philippe, Demaurex, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642294/ https://www.ncbi.nlm.nih.gov/pubmed/23508951 http://dx.doi.org/10.1074/jbc.M112.428128

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