Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex

The Ataxia Telangiectasia-Mutated (ATM) protein kinase is recruited to sites of double-strand DNA breaks by the Mre11/Rad50/Nbs1 (MRN) complex, which also facilitates ATM monomerization and activation. MRN exists in at least two distinct conformational states, dependent on ATP binding and hydrolysis...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Hoon, Mand, Michael R., Deshpande, Rajashree A., Kinoshita, Eri, Yang, Soo-Hyun, Wyman, Claire, Paull, Tanya T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
DNA and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642328/
https://www.ncbi.nlm.nih.gov/pubmed/23525106
http://dx.doi.org/10.1074/jbc.M113.460378

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