Human and Viral Golgi Anti-apoptotic Proteins (GAAPs) Oligomerize via Different Mechanisms and Monomeric GAAP Inhibits Apoptosis and Modulates Calcium

Golgi anti-apoptotic proteins (GAAPs) are hydrophobic proteins resident in membranes of the Golgi complex. They protect cells from a range of apoptotic stimuli, reduce the Ca(2+) content of intracellular stores, and regulate Ca(2+) fluxes. GAAP was discovered in camelpox virus, but it is highly cons...

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Detalles Bibliográficos
Autores principales: Saraiva, Nuno, Prole, David L., Carrara, Guia, de Motes, Carlos Maluquer, Johnson, Benjamin F., Byrne, Bernadette, Taylor, Colin W., Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642348/
https://www.ncbi.nlm.nih.gov/pubmed/23508950
http://dx.doi.org/10.1074/jbc.M112.414367

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