Cargando…
Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine
BACKGROUND: Epinephrine administered intramuscularly is the treatment of choice for anaphylaxis, and more than 1 dose is occasionally required. OBJECTIVE: To determine clinical background of anaphylaxis for improving the treatment, management, and prognosis of anaphylaxis. METHODS: Children who had...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643057/ https://www.ncbi.nlm.nih.gov/pubmed/23667834 http://dx.doi.org/10.5415/apallergy.2013.3.2.106 |
_version_ | 1782268255787810816 |
---|---|
author | Inoue, Naoyuki Yamamoto, Asuka |
author_facet | Inoue, Naoyuki Yamamoto, Asuka |
author_sort | Inoue, Naoyuki |
collection | PubMed |
description | BACKGROUND: Epinephrine administered intramuscularly is the treatment of choice for anaphylaxis, and more than 1 dose is occasionally required. OBJECTIVE: To determine clinical background of anaphylaxis for improving the treatment, management, and prognosis of anaphylaxis. METHODS: Children who had satisfied the diagnostic criteria for anaphylaxis according to the National Institute of Allergy and Infectious Disease Food Allergy and Anaphylaxis Network were selected from our hospital from April 1, 2009 to March 31, 2012. RESULTS: We analyzed 61 patients from the ages of 2 months to 14 years who satisfied the diagnostic criteria for anaphylaxis. Parents of 32 children (52.5%) reported that they had been administered single dose of epinephrine, and 3 children (4.9%) reported receiving multiple doses of epinephrine. The latter group experienced syncope more often (p = 0.049) than the former and suffered more often from comorbid allergic diseases (p = 0.043) that included either bronchial asthma, allergic rhinitis, or atopic dermatitis. Two (3.3%) children experienced biphasic reactions. Patients who experienced a biphasic reaction were more likely to have experienced syncope (p = 0.033), vomiting (p = 0.02), and administration of multiple doses of epinephrine (p = 0.0016). CONCLUSION: Our findings lead us to recommend that children receiving more than 1 injection of epinephrine should be observed for 24 hours, because it seems that children with requiring more than 1 injection of epinephrine might be have biphasic reactions. |
format | Online Article Text |
id | pubmed-3643057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-36430572013-05-10 Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine Inoue, Naoyuki Yamamoto, Asuka Asia Pac Allergy Original Article BACKGROUND: Epinephrine administered intramuscularly is the treatment of choice for anaphylaxis, and more than 1 dose is occasionally required. OBJECTIVE: To determine clinical background of anaphylaxis for improving the treatment, management, and prognosis of anaphylaxis. METHODS: Children who had satisfied the diagnostic criteria for anaphylaxis according to the National Institute of Allergy and Infectious Disease Food Allergy and Anaphylaxis Network were selected from our hospital from April 1, 2009 to March 31, 2012. RESULTS: We analyzed 61 patients from the ages of 2 months to 14 years who satisfied the diagnostic criteria for anaphylaxis. Parents of 32 children (52.5%) reported that they had been administered single dose of epinephrine, and 3 children (4.9%) reported receiving multiple doses of epinephrine. The latter group experienced syncope more often (p = 0.049) than the former and suffered more often from comorbid allergic diseases (p = 0.043) that included either bronchial asthma, allergic rhinitis, or atopic dermatitis. Two (3.3%) children experienced biphasic reactions. Patients who experienced a biphasic reaction were more likely to have experienced syncope (p = 0.033), vomiting (p = 0.02), and administration of multiple doses of epinephrine (p = 0.0016). CONCLUSION: Our findings lead us to recommend that children receiving more than 1 injection of epinephrine should be observed for 24 hours, because it seems that children with requiring more than 1 injection of epinephrine might be have biphasic reactions. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2013-04 2013-04-26 /pmc/articles/PMC3643057/ /pubmed/23667834 http://dx.doi.org/10.5415/apallergy.2013.3.2.106 Text en Copyright © 2013. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Inoue, Naoyuki Yamamoto, Asuka Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine |
title | Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine |
title_full | Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine |
title_fullStr | Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine |
title_full_unstemmed | Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine |
title_short | Clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine |
title_sort | clinical evaluation of pediatric anaphylaxis and the necessity for multiple doses of epinephrine |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643057/ https://www.ncbi.nlm.nih.gov/pubmed/23667834 http://dx.doi.org/10.5415/apallergy.2013.3.2.106 |
work_keys_str_mv | AT inouenaoyuki clinicalevaluationofpediatricanaphylaxisandthenecessityformultipledosesofepinephrine AT yamamotoasuka clinicalevaluationofpediatricanaphylaxisandthenecessityformultipledosesofepinephrine |