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Prevalence of latex allergy in spina bifida patients in Singapore
BACKGROUND: Latex allergy and its clinical presentation are rising in prevalence across the globe, especially amongst patients with spina bifida (SB). While studies have been well-established in Europe and America, data from Asia are limited. OBJECTIVE: The aim of this study is to investigate the sc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643061/ https://www.ncbi.nlm.nih.gov/pubmed/23667832 http://dx.doi.org/10.5415/apallergy.2013.3.2.96 |
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author | Chua, Xiuzhen Mohamed, Javid van Bever, Hugo PS |
author_facet | Chua, Xiuzhen Mohamed, Javid van Bever, Hugo PS |
author_sort | Chua, Xiuzhen |
collection | PubMed |
description | BACKGROUND: Latex allergy and its clinical presentation are rising in prevalence across the globe, especially amongst patients with spina bifida (SB). While studies have been well-established in Europe and America, data from Asia are limited. OBJECTIVE: The aim of this study is to investigate the scenario in Singapore. METHODS: 35 subjects with SB, aged 5 to 32 years answered a questionnaire and underwent skin prick test (SPT) using a latex solution, 3 common house dust mites and 3 commonly cross-reacting food allergens (banana, kiwi and avocado). We also noted the relation between latex sensitization with atopy and doctor-diagnosed allergy. The prevalence of cross-reactivity with fruits was also studied. RESULTS: Sensitization to latex (i.e. a positive SPT) was found in 16 (46%, 95% confidence interval 29%-63%) of the subjects. Only 5 (31%) of the subjects who were sensitized to latex had clinical manifestations. Atopy (i.e. positive SPT to house dust mites) was present in 23 (66%) of the subjects and 13 (57%) of them was also sensitized to latex. There was a positive trend between latex sensitization and atopy (81.2% vs. 52.6%, p = 0.076), as well as latex sensitization with those having both atopy and doctor-diagnosed allergy (i.e. asthma, allergic rhinitis, eczema, drug allergy) (93.8% vs. 63.2%, p = 0.032). Only 6 (38%) subjects had allergy to the food allergens tested. CONCLUSION: Almost half of the SB patients in Singapore are sensitized to latex. This number is comparable to that in Europe and America. Positive trend between latex sensitization and those with both atopy and doctor-diagnosed allergy (p = 0.032) is suggestive of a possible cause-effect relationship. |
format | Online Article Text |
id | pubmed-3643061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-36430612013-05-10 Prevalence of latex allergy in spina bifida patients in Singapore Chua, Xiuzhen Mohamed, Javid van Bever, Hugo PS Asia Pac Allergy Original Article BACKGROUND: Latex allergy and its clinical presentation are rising in prevalence across the globe, especially amongst patients with spina bifida (SB). While studies have been well-established in Europe and America, data from Asia are limited. OBJECTIVE: The aim of this study is to investigate the scenario in Singapore. METHODS: 35 subjects with SB, aged 5 to 32 years answered a questionnaire and underwent skin prick test (SPT) using a latex solution, 3 common house dust mites and 3 commonly cross-reacting food allergens (banana, kiwi and avocado). We also noted the relation between latex sensitization with atopy and doctor-diagnosed allergy. The prevalence of cross-reactivity with fruits was also studied. RESULTS: Sensitization to latex (i.e. a positive SPT) was found in 16 (46%, 95% confidence interval 29%-63%) of the subjects. Only 5 (31%) of the subjects who were sensitized to latex had clinical manifestations. Atopy (i.e. positive SPT to house dust mites) was present in 23 (66%) of the subjects and 13 (57%) of them was also sensitized to latex. There was a positive trend between latex sensitization and atopy (81.2% vs. 52.6%, p = 0.076), as well as latex sensitization with those having both atopy and doctor-diagnosed allergy (i.e. asthma, allergic rhinitis, eczema, drug allergy) (93.8% vs. 63.2%, p = 0.032). Only 6 (38%) subjects had allergy to the food allergens tested. CONCLUSION: Almost half of the SB patients in Singapore are sensitized to latex. This number is comparable to that in Europe and America. Positive trend between latex sensitization and those with both atopy and doctor-diagnosed allergy (p = 0.032) is suggestive of a possible cause-effect relationship. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2013-04 2013-04-26 /pmc/articles/PMC3643061/ /pubmed/23667832 http://dx.doi.org/10.5415/apallergy.2013.3.2.96 Text en Copyright © 2013. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chua, Xiuzhen Mohamed, Javid van Bever, Hugo PS Prevalence of latex allergy in spina bifida patients in Singapore |
title | Prevalence of latex allergy in spina bifida patients in Singapore |
title_full | Prevalence of latex allergy in spina bifida patients in Singapore |
title_fullStr | Prevalence of latex allergy in spina bifida patients in Singapore |
title_full_unstemmed | Prevalence of latex allergy in spina bifida patients in Singapore |
title_short | Prevalence of latex allergy in spina bifida patients in Singapore |
title_sort | prevalence of latex allergy in spina bifida patients in singapore |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643061/ https://www.ncbi.nlm.nih.gov/pubmed/23667832 http://dx.doi.org/10.5415/apallergy.2013.3.2.96 |
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