Insight to neoplastic thyroid lesions by fine needle aspiration cytology

BACKGROUND: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions. AIM: To study the cytology of neoplastic thyroid lesions to minimize surgical intervent...

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Autores principales: Rangaswamy, M, Narendra, KL, Patel, S, Gururajprasad, C, Manjunath, GV
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643357/
https://www.ncbi.nlm.nih.gov/pubmed/23661936
http://dx.doi.org/10.4103/0970-9371.107508
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author Rangaswamy, M
Narendra, KL
Patel, S
Gururajprasad, C
Manjunath, GV
author_facet Rangaswamy, M
Narendra, KL
Patel, S
Gururajprasad, C
Manjunath, GV
author_sort Rangaswamy, M
collection PubMed
description BACKGROUND: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions. AIM: To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study. MATERIALS AND METHODS: 100 cases of thyroid FNAC smears were analyzed and cyto-histopathological correlation was done in 47 cases. Galen and Gambino's method was used to calculate the sensitivity and positive predictive value. RESULTS: Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non-neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions. CONCLUSIONS: FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients.
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spelling pubmed-36433572013-05-09 Insight to neoplastic thyroid lesions by fine needle aspiration cytology Rangaswamy, M Narendra, KL Patel, S Gururajprasad, C Manjunath, GV J Cytol Original Article BACKGROUND: Fine needle aspiration cytology (FNAC) is a valuable adjunct to pre-operative screening in the diagnosis of thyroid nodules, and in most cases, it can distinguish between benign and malignant lesions. AIM: To study the cytology of neoplastic thyroid lesions to minimize surgical intervention and for confirmation of the diagnosis by histopathological study. MATERIALS AND METHODS: 100 cases of thyroid FNAC smears were analyzed and cyto-histopathological correlation was done in 47 cases. Galen and Gambino's method was used to calculate the sensitivity and positive predictive value. RESULTS: Of the 100 cases, 90 were diagnosed as neoplastic lesions by FNAC and ten cases as non-neoplastic lesions, which turned out to be neoplasms on histopathological study. Among 100 cases, 47 were biopsied and subjected to histopathological study. The sensitivity of FNAC was 75.60%, and positive predictive value was 83.78% for malignant lesions. CONCLUSIONS: FNAC is a rapid, efficient, cost-effective, relatively painless procedure with a high diagnostic accuracy. It has high rate of sensitivity and positive predictive value in diagnosing thyroid neoplastic lesions. Hence, it is a valuable tool in the diagnosis and management of patients. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3643357/ /pubmed/23661936 http://dx.doi.org/10.4103/0970-9371.107508 Text en Copyright: © Journal of Cytology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rangaswamy, M
Narendra, KL
Patel, S
Gururajprasad, C
Manjunath, GV
Insight to neoplastic thyroid lesions by fine needle aspiration cytology
title Insight to neoplastic thyroid lesions by fine needle aspiration cytology
title_full Insight to neoplastic thyroid lesions by fine needle aspiration cytology
title_fullStr Insight to neoplastic thyroid lesions by fine needle aspiration cytology
title_full_unstemmed Insight to neoplastic thyroid lesions by fine needle aspiration cytology
title_short Insight to neoplastic thyroid lesions by fine needle aspiration cytology
title_sort insight to neoplastic thyroid lesions by fine needle aspiration cytology
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643357/
https://www.ncbi.nlm.nih.gov/pubmed/23661936
http://dx.doi.org/10.4103/0970-9371.107508
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