Cargando…

Dissection of cell cycle–dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling

DNA methyltransferase 1 (Dnmt1) reestablishes methylation of hemimethylated CpG sites generated during DNA replication in mammalian cells. Two subdomains, the proliferating cell nuclear antigen (PCNA)-binding domain (PBD) and the targeting sequence (TS) domain, target Dnmt1 to the replication sites...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schneider, Katrin, Fuchs, Christiane, Dobay, Akos, Rottach, Andrea, Qin, Weihua, Wolf, Patricia, Álvarez-Castro, José M., Nalaskowski, Marcus M., Kremmer, Elisabeth, Schmid, Volker, Leonhardt, Heinrich, Schermelleh, Lothar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643600/ https://www.ncbi.nlm.nih.gov/pubmed/23535145 http://dx.doi.org/10.1093/nar/gkt191

Ejemplares similares

TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
por: Müller, Udo, et al.
Publicado: (2014)

H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
por: Bönisch, Clemens, et al.
Publicado: (2012)

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1
por: Felle, Max, et al.
Publicado: (2011)

The multi-domain protein Np95 connects DNA methylation and histone modification
por: Rottach, Andrea, et al.
Publicado: (2010)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants
por: Van Emburgh, Beth O., et al.
Publicado: (2011)

Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L
por: Jurkowska, Renata Z., et al.
Publicado: (2008)

Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
por: Stepper, Peter, et al.
Publicado: (2017)

DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells
por: Veland, Nicolas, et al.
Publicado: (2019)

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail
por: Zhang, Yingying, et al.
Publicado: (2010)

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing
por: O’Geen, Henriette, et al.
Publicado: (2022)

Transient DNMT1 suppression reveals hidden heritable marks in the genome
por: McGraw, Serge, et al.
Publicado: (2015)

Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase
por: Dukatz, Michael, et al.
Publicado: (2020)

On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase
por: Adam, Sabrina, et al.
Publicado: (2023)

Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components
por: Ugur, Enes, et al.
Publicado: (2023)

Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation
por: Deplus, Rachel, et al.
Publicado: (2014)

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation
por: Thompson, Joyce J, et al.
Publicado: (2018)

Dnmt1 binds and represses genomic retroelements via DNA methylation in mouse early embryos
por: Min, Byungkuk, et al.
Publicado: (2020)

The splicing regulator SLU7 is required to preserve DNMT1 protein stability and DNA methylation
por: Recalde, Miriam, et al.
Publicado: (2021)

Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP
por: Zhang, Yuxia, et al.
Publicado: (2012)

Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context
por: Espada, Jesús, et al.
Publicado: (2011)

SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1
por: Zhang, Huifang, et al.
Publicado: (2019)

GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair
por: Lee, Bongyong, et al.
Publicado: (2012)

ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing
por: Gatto, Sole, et al.
Publicado: (2017)

A role for LSH in facilitating DNA methylation by DNMT1 through enhancing UHRF1 chromatin association
por: Han, Mengmeng, et al.
Publicado: (2020)

A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA
por: Shen, Li, et al.
Publicado: (2010)

Targeting of 5-aza-2′-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme
por: Patel, Katan, et al.
Publicado: (2010)

Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression
por: Estève, Pierre-Olivier, et al.
Publicado: (2016)

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts
por: Zhang, Donghong, et al.
Publicado: (2017)

Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency
por: Qin, Weihua, et al.
Publicado: (2021)

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes
por: Clements, Eriko G., et al.
Publicado: (2012)

Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
por: Bultmann, Sebastian, et al.
Publicado: (2012)

Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster
por: Villar-Garea, Ana, et al.
Publicado: (2012)

Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage
por: de la Vega, Laureano, et al.
Publicado: (2013)

GSK-3484862 targets DNMT1 for degradation in cells
por: Chen, Qin, et al.
Publicado: (2023)

KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1
por: Borgel, Julie, et al.
Publicado: (2017)

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
por: Trauernicht, Max, et al.
Publicado: (2023)

Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise
por: Ludwig, Anne K., et al.
Publicado: (2017)

The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification
por: Ullius, Andrea, et al.
Publicado: (2014)

Dissecting the behavior and function of MBD3 in DNA methylation homeostasis by single-molecule spectroscopy and microscopy
por: Cui, Yi, et al.
Publicado: (2015)

TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation
por: Stolz, Paul, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g255a9h3uocflfbro7r9otef2d