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The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma: Single Institution Experience
OBJECTIVE: To assess the impact of close or positive surgical margins on the outcome, and to determine whether margin status influence the recurrence rate and the overall survival for patients with head and neck cancers. METHODS: Records from 1996 to 2001 of 413 patients with primary head and neck s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Anti-Cancer Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643636/ https://www.ncbi.nlm.nih.gov/pubmed/23691451 http://dx.doi.org/10.3969/j.issn.2095-3941.2012.01.005 |
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author | Eldeeb, Hany Macmillan, Craig Elwell, Christine Hammod, Abdulla |
author_facet | Eldeeb, Hany Macmillan, Craig Elwell, Christine Hammod, Abdulla |
author_sort | Eldeeb, Hany |
collection | PubMed |
description | OBJECTIVE: To assess the impact of close or positive surgical margins on the outcome, and to determine whether margin status influence the recurrence rate and the overall survival for patients with head and neck cancers. METHODS: Records from 1996 to 2001 of 413 patients with primary head and neck squamous cell carcinoma (SCC) treated with surgery as the first line treatment were analysed. Of these patients, 82 were eligible for the study. Patients were followed up for 5 years. RESULTS: Patients with margins between 5-10 mm had 50% recurrence rate (RR), those with surgical margins between 1-5 mm had RR of 59% and those with positive surgical margins had RR of 90% (P=0.004). The 5-year survival rates were 54%, 39% and 10%, respectively (P=0.002). CONCLUSIONS: Unsatisfactory surgical margin is an independent risk factor for recurrence free survival as well as overall survival regardless of the other tumor and patient characteristics. |
format | Online Article Text |
id | pubmed-3643636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Chinese Anti-Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-36436362013-05-20 The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma: Single Institution Experience Eldeeb, Hany Macmillan, Craig Elwell, Christine Hammod, Abdulla Cancer Biol Med Original Article OBJECTIVE: To assess the impact of close or positive surgical margins on the outcome, and to determine whether margin status influence the recurrence rate and the overall survival for patients with head and neck cancers. METHODS: Records from 1996 to 2001 of 413 patients with primary head and neck squamous cell carcinoma (SCC) treated with surgery as the first line treatment were analysed. Of these patients, 82 were eligible for the study. Patients were followed up for 5 years. RESULTS: Patients with margins between 5-10 mm had 50% recurrence rate (RR), those with surgical margins between 1-5 mm had RR of 59% and those with positive surgical margins had RR of 90% (P=0.004). The 5-year survival rates were 54%, 39% and 10%, respectively (P=0.002). CONCLUSIONS: Unsatisfactory surgical margin is an independent risk factor for recurrence free survival as well as overall survival regardless of the other tumor and patient characteristics. Chinese Anti-Cancer Association 2012-03 /pmc/articles/PMC3643636/ /pubmed/23691451 http://dx.doi.org/10.3969/j.issn.2095-3941.2012.01.005 Text en 2012 Cancer Biology & Medicine This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Original Article Eldeeb, Hany Macmillan, Craig Elwell, Christine Hammod, Abdulla The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma: Single Institution Experience |
title | The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma: Single Institution Experience |
title_full | The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma: Single Institution Experience |
title_fullStr | The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma: Single Institution Experience |
title_full_unstemmed | The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma: Single Institution Experience |
title_short | The Effect of the Surgical Margins on the Outcome of Patients with Head and Neck Squamous Cell Carcinoma: Single Institution Experience |
title_sort | effect of the surgical margins on the outcome of patients with head and neck squamous cell carcinoma: single institution experience |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643636/ https://www.ncbi.nlm.nih.gov/pubmed/23691451 http://dx.doi.org/10.3969/j.issn.2095-3941.2012.01.005 |
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