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Photodynamic Therapy for Gynecological Diseases and Breast Cancer

Photodynamic therapy (PDT) is a minimally invasive and promising new method in cancer treatment. Cytotoxic reactive oxygen species (ROS) are generated by the tissue-localized non-toxic sensitizer upon illumination and in the presence of oxygen. Thus, selective destruction of a targeted tumor may be...

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Detalles Bibliográficos
Autores principales: Shishkova, Natashis, Kuznetsova, Olga, Berezov, Temirbolat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Anti-Cancer Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643637/
https://www.ncbi.nlm.nih.gov/pubmed/23691448
http://dx.doi.org/10.3969/j.issn.2095-3941.2012.01.002
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author Shishkova, Natashis
Kuznetsova, Olga
Berezov, Temirbolat
author_facet Shishkova, Natashis
Kuznetsova, Olga
Berezov, Temirbolat
author_sort Shishkova, Natashis
collection PubMed
description Photodynamic therapy (PDT) is a minimally invasive and promising new method in cancer treatment. Cytotoxic reactive oxygen species (ROS) are generated by the tissue-localized non-toxic sensitizer upon illumination and in the presence of oxygen. Thus, selective destruction of a targeted tumor may be achieved. Compared with traditional cancer treatment, PDI has advantages including higher selectivity and lower rate of toxicity. The high degree of selectivity of the proposed method was applied to cancer diagnosis using fluorescence. This article reviews previous studies done on PDT treatment and photodetection of cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, ovarian and breast cancer, and PDT application in treating non-cancer lesions. The article also highlights the clinical responses to PDT, and discusses the possibility of enhancing treatment efficacy by combination with immunotherapy and targeted therapy.
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spelling pubmed-36436372013-05-20 Photodynamic Therapy for Gynecological Diseases and Breast Cancer Shishkova, Natashis Kuznetsova, Olga Berezov, Temirbolat Cancer Biol Med Review Photodynamic therapy (PDT) is a minimally invasive and promising new method in cancer treatment. Cytotoxic reactive oxygen species (ROS) are generated by the tissue-localized non-toxic sensitizer upon illumination and in the presence of oxygen. Thus, selective destruction of a targeted tumor may be achieved. Compared with traditional cancer treatment, PDI has advantages including higher selectivity and lower rate of toxicity. The high degree of selectivity of the proposed method was applied to cancer diagnosis using fluorescence. This article reviews previous studies done on PDT treatment and photodetection of cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, ovarian and breast cancer, and PDT application in treating non-cancer lesions. The article also highlights the clinical responses to PDT, and discusses the possibility of enhancing treatment efficacy by combination with immunotherapy and targeted therapy. Chinese Anti-Cancer Association 2012-03 /pmc/articles/PMC3643637/ /pubmed/23691448 http://dx.doi.org/10.3969/j.issn.2095-3941.2012.01.002 Text en 2012 Cancer Biology & Medicine This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Review
Shishkova, Natashis
Kuznetsova, Olga
Berezov, Temirbolat
Photodynamic Therapy for Gynecological Diseases and Breast Cancer
title Photodynamic Therapy for Gynecological Diseases and Breast Cancer
title_full Photodynamic Therapy for Gynecological Diseases and Breast Cancer
title_fullStr Photodynamic Therapy for Gynecological Diseases and Breast Cancer
title_full_unstemmed Photodynamic Therapy for Gynecological Diseases and Breast Cancer
title_short Photodynamic Therapy for Gynecological Diseases and Breast Cancer
title_sort photodynamic therapy for gynecological diseases and breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643637/
https://www.ncbi.nlm.nih.gov/pubmed/23691448
http://dx.doi.org/10.3969/j.issn.2095-3941.2012.01.002
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