Heat Shock Protein 90 Inhibitors Repress Latent Membrane Protein 1 (LMP1) Expression and Proliferation of Epstein-Barr Virus-Positive Natural Killer Cell Lymphoma

Epstein-Barr virus (EBV) LMP1 is a major oncoprotein expressed in latent infection. It functions as a TNFR family member and constitutively activates cellular signals, such as NFκB, MAPK, JAK/STAT and AKT. We here screened small molecule inhibitors and isolated HSP90 inhibitors, Radicicol and 17-AAG...

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Detalles Bibliográficos
Autores principales: Murata, Takayuki, Iwata, Seiko, Siddiquey, Mohammed Nure Alam, Kanazawa, Tetsuhiro, Goshima, Fumi, Kawashima, Daisuke, Kimura, Hiroshi, Tsurumi, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643901/
https://www.ncbi.nlm.nih.gov/pubmed/23658841
http://dx.doi.org/10.1371/journal.pone.0063566

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