A Lympho-Follicular Microenvironment Is Required for Pathological Prion Protein Deposition in Chronically Inflamed Tissues from Scrapie-Affected Sheep

In sheep scrapie, pathological prion protein (PrP(Sc)) deposition occurs in the lymphoreticular and central nervous systems. We investigated PrP(Sc) distribution in scrapie-affected sheep showing simultaneous evidence of chronic lymphofollicular, lymphoproliferative/non-lymphofollicular, and/or gran...

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Detalles Bibliográficos
Autores principales: Maestrale, Caterina, Di Guardo, Giovanni, Cancedda, Maria Giovanna, Marruchella, Giuseppe, Masia, Mariangela, Sechi, Stefania, Macciocu, Simonetta, Santucciu, Cinzia, Petruzzi, Mara, Ligios, Ciriaco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643908/
https://www.ncbi.nlm.nih.gov/pubmed/23658779
http://dx.doi.org/10.1371/journal.pone.0062830

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