Cargando…

Evaluating Power and Type 1 Error in Large Pedigree Analyses of Binary Traits

Studying population isolates with large, complex pedigrees has many advantages for discovering genetic susceptibility loci; however, statistical analyses can be computationally challenging. Allelic association tests need to be corrected for relatedness among study participants, and linkage analyses...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cummings, Anna C., Torstenson, Eric, Davis, Mary F., D’Aoust, Laura N., Scott, William K., Pericak-Vance, Margaret A., Bush, William S., Haines, Jonathan L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643945/ https://www.ncbi.nlm.nih.gov/pubmed/23658753 http://dx.doi.org/10.1371/journal.pone.0062615

Ejemplares similares

Examination of Candidate Exonic Variants for Association to Alzheimer Disease in the Amish
por: D’Aoust, Laura N., et al.
Publicado: (2015)

Exome Sequencing of a Multigenerational Human Pedigree
por: Hedges, Dale, et al.
Publicado: (2009)

Correction: Exome Sequencing of a Multigenerational Human Pedigree
por: Hedges, Dale J., et al.
Publicado: (2009)

KIAA1462, A Coronary Artery Disease Associated Gene, Is a Candidate Gene for Late Onset Alzheimer Disease in APOE Carriers
por: Murdock, Deborah G., et al.
Publicado: (2013)

Effect of errors in pedigree on the accuracy of estimated breeding value for carcass traits in Korean Hanwoo cattle
por: Nwogwugwu, Chiemela Peter, et al.
Publicado: (2020)

Automated extraction of clinical traits of multiple sclerosis in electronic medical records
por: Davis, Mary F, et al.
Publicado: (2013)

Pedigree and genotype errors in the Framingham Heart Study
por: Brush, Gerry, et al.
Publicado: (2003)

Effects of pedigree errors on the efficiency of conservation decisions
por: Oliehoek, Pieter A, et al.
Publicado: (2009)

Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration
por: Osterman, Michael D., et al.
Publicado: (2022)

Leveraging family history in genetic association analyses of binary traits
por: Zhang, Yixin, et al.
Publicado: (2022)

Quantitative trait locus analysis of hybrid pedigrees: variance-components model, inbreeding parameter, and power
por: Svischeva, Gulnara R
Publicado: (2007)

A powerful parent-of-origin effects test for qualitative traits on X chromosome in general pedigrees
por: Zou, Qi-Lei, et al.
Publicado: (2018)

Using linkage analysis of large pedigrees to guide association analyses
por: Choi, Seung-Hoan, et al.
Publicado: (2011)

Evaluating outlier loci and their effect on the identification of pedigree errors
por: Wang, Ke-Sheng, et al.
Publicado: (2005)

“Noisy beets”: impact of phenotyping errors on genomic predictions for binary traits in Beta vulgaris
por: Biscarini, Filippo, et al.
Publicado: (2016)

The Impact of the Human Genome Project on Complex Disease
por: Cooke Bailey, Jessica N., et al.
Publicado: (2014)

Identity by descent and association analysis of dichotomous traits based on large pedigrees
por: Liu, Tian, et al.
Publicado: (2011)

Management of inflammatory bowel disease with Clostridium difficile infection
por: D’Aoust, Julie, et al.
Publicado: (2017)

Detecting genotyping errors at Schistosoma japonicum microsatellites with pedigree information
por: Gao, Yu-Meng, et al.
Publicado: (2015)

An evaluation of approaches for rare variant association analyses of binary traits in related samples
por: Chen, Ming-Huei, et al.
Publicado: (2021)

LD-Spline: Mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium
por: Bush, William S, et al.
Publicado: (2009)

FamAgg: an R package to evaluate familial aggregation of traits in large pedigrees
por: Rainer, Johannes, et al.
Publicado: (2016)

A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data
por: Buchanan, Carrie C, et al.
Publicado: (2012)

Vertebral Osteomyelitis: An Under-Recognized Infectious Complication in Patients on Home Parenteral Nutrition
por: Huard, Genevieve, et al.
Publicado: (2014)

The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
por: Cooke Bailey, Jessica N., et al.
Publicado: (2016)

Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models
por: Hall, Jacob B., et al.
Publicado: (2015)

Bayesian Linkage Analysis of Categorical Traits for Arbitrary Pedigree Designs
por: Brisbin, Abra, et al.
Publicado: (2010)

The hidden factor: accounting for covariate effects in power and sample size computation for a binary trait
por: Zhang, Ziang, et al.
Publicado: (2023)

Increasing the Number of Faculty With CNE(®) Certification: A Statewide Initiative
por: Daw, Peggy, et al.
Publicado: (2022)

Pedigree and Molecular Analyses in the Assessment of Genetic Variability of the Polish Greyhound
por: Goleman, Małgorzata, et al.
Publicado: (2021)

QuickPed: an online tool for drawing pedigrees and analysing relatedness
por: Vigeland, Magnus D.
Publicado: (2022)

Quantitative trait locus linkage analysis in a large Amish pedigree identifies novel candidate loci for erythrocyte traits
por: Hinckley, Jesse D, et al.
Publicado: (2013)

Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees
por: Chen, Wei-Min, et al.
Publicado: (2011)

A regression based transmission/disequilibrium test for binary traits: the power of joint tests for linkage and association
por: Larkin, Emma K, et al.
Publicado: (2005)

Heritability and Pedigree Analyses of Hypertrophic Cardiomyopathy in Rhesus Macaques (Macaca Mulatta)
por: Ueda, Yu, et al.
Publicado: (2021)

Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders
por: Cannon, Dale S, et al.
Publicado: (2010)

Large‐scale sequencing studies expand the known genetic architecture of Alzheimer's disease
por: Xue, Diane, et al.
Publicado: (2021)

Identification of Pedigree Relationship from Genome Sharing
por: Hill, William G., et al.
Publicado: (2013)

Sampling genotypes in large pedigrees with loops
por: Fernández, Soledad A, et al.
Publicado: (2001)

Local Ancestry Inference in Large Pedigrees
por: Wang, Heming, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bs941359m8v0aajrnfhjkik5nr