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A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study

BACKGROUND: During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of...

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Autores principales: Wie, Seong-Heon, So, Byung Hak, Song, Joon Young, Cheong, Hee Jin, Seo, Yu Bin, Choi, Sung Hyuk, Noh, Ji Yun, Baek, Ji Hyeon, Lee, Jin Soo, Kim, Hyo Youl, Kim, Young Keun, Choi, Won Suk, Lee, Jacob, Jeong, Hye Won, Kim, Woo Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643978/
https://www.ncbi.nlm.nih.gov/pubmed/23671624
http://dx.doi.org/10.1371/journal.pone.0062685
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author Wie, Seong-Heon
So, Byung Hak
Song, Joon Young
Cheong, Hee Jin
Seo, Yu Bin
Choi, Sung Hyuk
Noh, Ji Yun
Baek, Ji Hyeon
Lee, Jin Soo
Kim, Hyo Youl
Kim, Young Keun
Choi, Won Suk
Lee, Jacob
Jeong, Hye Won
Kim, Woo Joo
author_facet Wie, Seong-Heon
So, Byung Hak
Song, Joon Young
Cheong, Hee Jin
Seo, Yu Bin
Choi, Sung Hyuk
Noh, Ji Yun
Baek, Ji Hyeon
Lee, Jin Soo
Kim, Hyo Youl
Kim, Young Keun
Choi, Won Suk
Lee, Jacob
Jeong, Hye Won
Kim, Woo Joo
author_sort Wie, Seong-Heon
collection PubMed
description BACKGROUND: During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05). CONCLUSIONS: The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza.
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spelling pubmed-36439782013-05-13 A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study Wie, Seong-Heon So, Byung Hak Song, Joon Young Cheong, Hee Jin Seo, Yu Bin Choi, Sung Hyuk Noh, Ji Yun Baek, Ji Hyeon Lee, Jin Soo Kim, Hyo Youl Kim, Young Keun Choi, Won Suk Lee, Jacob Jeong, Hye Won Kim, Woo Joo PLoS One Research Article BACKGROUND: During the 2011/2012 winter influenza season in the Republic of Korea, influenza A (H3N2) was the predominant virus in the first peak period of influenza activity during the second half of January 2012. On the other hand, influenza B was the predominant virus in the second peak period of influenza activity during the second half of March 2012. The objectives of this study were to compare the clinical and epidemiological characteristics of patients with laboratory-confirmed influenza A or influenza B. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed data from 2,129 adult patients with influenza-like illnesses who visited the emergency rooms of seven university hospitals in Korea from October 2011 to May 2012. Of 850 patients with laboratory-confirmed influenza, 656 (77.2%) had influenza A (H3N2), and 194 (22.8%) influenza B. Age, and the frequencies of cardiovascular disorders, diabetes, hypertension were significantly higher in patients with influenza A (H3N2) (P<0.05). The frequencies of leukopenia or thrombocytopenia in patients with influenza B at initial presentation were statistically higher than those in patients with influenza A (H3N2) (P<0.05). The rate of hospitalization, and length of hospital stay were statistically higher in patients with influenza A (H3N2) (P<0.05), and of the 79 hospitalized patients, the frequency of diabetes, hypertension, cases having at least one of the comorbid conditions, and the proportion of elderly were significantly higher in patients with influenza A (H3N2) (P<0.05). CONCLUSIONS: The proportion of males to females and elderly population were significantly higher for influenza A (H3N2) patients group compared with influenza B group. Hypertension, diabetes, chronic lung diseases, cardiovascular disorders, and neuromuscular diseases were independently associated with hospitalization due to influenza. Physicians should assess and treat the underlying comorbid conditions as well as influenza viral infections for the appropriate management of patients with influenza. Public Library of Science 2013-05-03 /pmc/articles/PMC3643978/ /pubmed/23671624 http://dx.doi.org/10.1371/journal.pone.0062685 Text en © 2013 Wie et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wie, Seong-Heon
So, Byung Hak
Song, Joon Young
Cheong, Hee Jin
Seo, Yu Bin
Choi, Sung Hyuk
Noh, Ji Yun
Baek, Ji Hyeon
Lee, Jin Soo
Kim, Hyo Youl
Kim, Young Keun
Choi, Won Suk
Lee, Jacob
Jeong, Hye Won
Kim, Woo Joo
A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study
title A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study
title_full A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study
title_fullStr A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study
title_full_unstemmed A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study
title_short A Comparison of the Clinical and Epidemiological Characteristics of Adult Patients with Laboratory-Confirmed Influenza A or B during the 2011–2012 Influenza Season in Korea: A Multi-Center Study
title_sort comparison of the clinical and epidemiological characteristics of adult patients with laboratory-confirmed influenza a or b during the 2011–2012 influenza season in korea: a multi-center study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643978/
https://www.ncbi.nlm.nih.gov/pubmed/23671624
http://dx.doi.org/10.1371/journal.pone.0062685
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