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Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD
The deubiquitinase CYLD acts as a key negative regulator to tightly control overactive inflammation. Most anti-inflammatory strategies have focused on directly targeting the positive regulator, which often results in significant side effects such as suppression of the host defence response. Here, we...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644066/ https://www.ncbi.nlm.nih.gov/pubmed/23575688 http://dx.doi.org/10.1038/ncomms2674 |