Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Two major processes govern T cell proliferation and survival: interleukin-7-mediated homeostasis and antigen-induced selection. How cells transit between the two states is unknown. Here we show that T cell receptor ligation actively inhibits homeostatic survival signals while initiating a new, domin...

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Detalles Bibliográficos
Autores principales: Koenen, Paul, Heinzel, Susanne, Carrington, Emma M., Happo, Lina, Alexander, Warren S., Zhang, Jian-Guo, Herold, Marco J., Scott, Clare L., Lew, Andrew M., Strasser, Andreas, Hodgkin, Philip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644093/
https://www.ncbi.nlm.nih.gov/pubmed/23591902
http://dx.doi.org/10.1038/ncomms2719

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