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Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region

Smad2/3-mediated transforming growth factor β signalling and the Ras-Raf-Mek-Erk cascade have important roles in stem cell and development and tissue homeostasis. However, it remains unknown whether Raf kinases directly crosstalk with Smad2/3 signalling and how this would regulate embryonic developm...

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Detalles Bibliográficos
Autores principales:	Liu, Xingfeng, Xiong, Cong, Jia, Shunji, Zhang, Yu, Chen, Ye-Guang, Wang, Qiang, Meng, Anming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644095/ https://www.ncbi.nlm.nih.gov/pubmed/23591895 http://dx.doi.org/10.1038/ncomms2762

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