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Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study

BACKGROUND: Pediatric health-related quality of life (HRQL) measures explore multiple domains of HRQL. To ease administration, burden, and implementation, we created a 7-item unidimensional global HRQL scale for children. This paper evaluates the psychometric properties of the global HRQL scale in c...

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Autores principales: Rodday, Angie Mae, Terrin, Norma, Parsons, Susan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644228/
https://www.ncbi.nlm.nih.gov/pubmed/23442200
http://dx.doi.org/10.1186/1477-7525-11-26
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author Rodday, Angie Mae
Terrin, Norma
Parsons, Susan K
author_facet Rodday, Angie Mae
Terrin, Norma
Parsons, Susan K
author_sort Rodday, Angie Mae
collection PubMed
description BACKGROUND: Pediatric health-related quality of life (HRQL) measures explore multiple domains of HRQL. To ease administration, burden, and implementation, we created a 7-item unidimensional global HRQL scale for children. This paper evaluates the psychometric properties of the global HRQL scale in children undergoing hematopoietic stem cell transplant (HSCT) and describes the trajectory of global HRQL scores over the 12-month course following HSCT. METHODS: As part of two longitudinal HSCT studies, HRQL was collected on 312 parent–child dyads using the Child Health Ratings Inventories. Parents of children aged 5–18 completed the pediatric global HRQL scale about their child and 117 adolescents completed the scale themselves. Psychometric properties were compared across both raters. Two repeated measures models were built to describe trajectories of (1) global HRQL for all children based on parent proxy report and (2) global HRQL for adolescents based on adolescent self-report and parent proxy report. RESULTS: Internal consistency reliability was high for parent proxy report and adolescent self-report (Cronbach’s alpha 0.9, 0.8, respectively). Unidimensionality was verified using principal components analysis. Both models indicated decreased global HRQL in the presence of early complications related to HSCT and Model 1 further indicated decreased HRQL in the presence of later complications. Model 2 showed that parent proxies reported lower global HRQL scores than adolescent self-report. CONCLUSIONS: This study has demonstrated the unidimensionality and strong psychometric properties of a 7-item global HRQL scale in a sample of children undergoing HSCT. Despite its brevity, scale scores vary in clinically meaningful ways. Future applications of this scale are encouraged.
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spelling pubmed-36442282013-05-05 Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study Rodday, Angie Mae Terrin, Norma Parsons, Susan K Health Qual Life Outcomes Research BACKGROUND: Pediatric health-related quality of life (HRQL) measures explore multiple domains of HRQL. To ease administration, burden, and implementation, we created a 7-item unidimensional global HRQL scale for children. This paper evaluates the psychometric properties of the global HRQL scale in children undergoing hematopoietic stem cell transplant (HSCT) and describes the trajectory of global HRQL scores over the 12-month course following HSCT. METHODS: As part of two longitudinal HSCT studies, HRQL was collected on 312 parent–child dyads using the Child Health Ratings Inventories. Parents of children aged 5–18 completed the pediatric global HRQL scale about their child and 117 adolescents completed the scale themselves. Psychometric properties were compared across both raters. Two repeated measures models were built to describe trajectories of (1) global HRQL for all children based on parent proxy report and (2) global HRQL for adolescents based on adolescent self-report and parent proxy report. RESULTS: Internal consistency reliability was high for parent proxy report and adolescent self-report (Cronbach’s alpha 0.9, 0.8, respectively). Unidimensionality was verified using principal components analysis. Both models indicated decreased global HRQL in the presence of early complications related to HSCT and Model 1 further indicated decreased HRQL in the presence of later complications. Model 2 showed that parent proxies reported lower global HRQL scores than adolescent self-report. CONCLUSIONS: This study has demonstrated the unidimensionality and strong psychometric properties of a 7-item global HRQL scale in a sample of children undergoing HSCT. Despite its brevity, scale scores vary in clinically meaningful ways. Future applications of this scale are encouraged. BioMed Central 2013-02-26 /pmc/articles/PMC3644228/ /pubmed/23442200 http://dx.doi.org/10.1186/1477-7525-11-26 Text en Copyright © 2013 Rodday et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Rodday, Angie Mae
Terrin, Norma
Parsons, Susan K
Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study
title Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study
title_full Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study
title_fullStr Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study
title_full_unstemmed Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study
title_short Measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study
title_sort measuring global health-related quality of life in children undergoing hematopoietic stem cell transplant: a longitudinal study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644228/
https://www.ncbi.nlm.nih.gov/pubmed/23442200
http://dx.doi.org/10.1186/1477-7525-11-26
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