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Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH

BACKGROUND: Data describing real-life management and treatment of community-acquired pneumonia (CAP) in Europe are limited. REACH (http://NCT01293435) was a retrospective, observational study collecting data on the management of EU patients hospitalized with CAP. The purpose of this study was to und...

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Autores principales: Blasi, Francesco, Garau, Javier, Medina, Jesús, Ávila, Marco, McBride, Kyle, Ostermann, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644236/
https://www.ncbi.nlm.nih.gov/pubmed/23586347
http://dx.doi.org/10.1186/1465-9921-14-44
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author Blasi, Francesco
Garau, Javier
Medina, Jesús
Ávila, Marco
McBride, Kyle
Ostermann, Helmut
author_facet Blasi, Francesco
Garau, Javier
Medina, Jesús
Ávila, Marco
McBride, Kyle
Ostermann, Helmut
author_sort Blasi, Francesco
collection PubMed
description BACKGROUND: Data describing real-life management and treatment of community-acquired pneumonia (CAP) in Europe are limited. REACH (http://NCT01293435) was a retrospective, observational study collecting data on the management of EU patients hospitalized with CAP. The purpose of this study was to understand patient and disease characteristics in patients hospitalized with CAP and to review current clinical practices and outcomes. METHODS: Patients were aged ≥18 years, hospitalized with CAP between March 2010 and February 2011, and requiring in-hospital treatment with intravenous antibiotics. An electronic Case Report Form was used to collect patient, disease and treatment variables, including type of CAP, medical history, treatment setting, antibiotics administered and clinical outcomes. RESULTS: Patients (N = 2,039) were recruited from 128 centres in ten EU countries (Belgium, France, Germany, Greece, Italy, the Netherlands, Portugal, Spain, Turkey, UK). The majority of patients were aged ≥65 years (56.4%) and had CAP only (78.8%). Initial antibiotic treatment modification occurred in 28.9% of patients and was more likely in certain groups (patients with comorbidities; more severely ill patients; patients with healthcare-associated pneumonia, immunosuppression or recurrent episodes of CAP). Streamlining (de-escalation) of therapy occurred in 5.1% of patients. Mean length of hospital stay was 12.6 days and overall mortality was 7.2%. CONCLUSION: These data provide a current overview of clinical practice in patients with CAP in EU hospitals, revealing high rates of initial antibiotic treatment modification. The findings may precipitate reassessment of optimal management regimens for hospitalized CAP patients.
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spelling pubmed-36442362013-05-05 Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH Blasi, Francesco Garau, Javier Medina, Jesús Ávila, Marco McBride, Kyle Ostermann, Helmut Respir Res Research BACKGROUND: Data describing real-life management and treatment of community-acquired pneumonia (CAP) in Europe are limited. REACH (http://NCT01293435) was a retrospective, observational study collecting data on the management of EU patients hospitalized with CAP. The purpose of this study was to understand patient and disease characteristics in patients hospitalized with CAP and to review current clinical practices and outcomes. METHODS: Patients were aged ≥18 years, hospitalized with CAP between March 2010 and February 2011, and requiring in-hospital treatment with intravenous antibiotics. An electronic Case Report Form was used to collect patient, disease and treatment variables, including type of CAP, medical history, treatment setting, antibiotics administered and clinical outcomes. RESULTS: Patients (N = 2,039) were recruited from 128 centres in ten EU countries (Belgium, France, Germany, Greece, Italy, the Netherlands, Portugal, Spain, Turkey, UK). The majority of patients were aged ≥65 years (56.4%) and had CAP only (78.8%). Initial antibiotic treatment modification occurred in 28.9% of patients and was more likely in certain groups (patients with comorbidities; more severely ill patients; patients with healthcare-associated pneumonia, immunosuppression or recurrent episodes of CAP). Streamlining (de-escalation) of therapy occurred in 5.1% of patients. Mean length of hospital stay was 12.6 days and overall mortality was 7.2%. CONCLUSION: These data provide a current overview of clinical practice in patients with CAP in EU hospitals, revealing high rates of initial antibiotic treatment modification. The findings may precipitate reassessment of optimal management regimens for hospitalized CAP patients. BioMed Central 2013 2013-04-15 /pmc/articles/PMC3644236/ /pubmed/23586347 http://dx.doi.org/10.1186/1465-9921-14-44 Text en Copyright © 2013 Blasi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Blasi, Francesco
Garau, Javier
Medina, Jesús
Ávila, Marco
McBride, Kyle
Ostermann, Helmut
Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH
title Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH
title_full Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH
title_fullStr Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH
title_full_unstemmed Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH
title_short Current management of patients hospitalized with community-acquired pneumonia across Europe: outcomes from REACH
title_sort current management of patients hospitalized with community-acquired pneumonia across europe: outcomes from reach
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644236/
https://www.ncbi.nlm.nih.gov/pubmed/23586347
http://dx.doi.org/10.1186/1465-9921-14-44
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