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Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes
Sharp wave-ripples (SWRs) are population oscillatory patterns in hippocampal LFPs during deep sleep and immobility, involved in the replay of memories acquired during wakefulness. SWRs have been extensively studied, but their exact generation mechanism is still unknown. A computational model has sug...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644622/ https://www.ncbi.nlm.nih.gov/pubmed/23653599 http://dx.doi.org/10.3389/fnsys.2013.00013 |
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author | Cutsuridis, Vassilis Taxidis, Jiannis |
author_facet | Cutsuridis, Vassilis Taxidis, Jiannis |
author_sort | Cutsuridis, Vassilis |
collection | PubMed |
description | Sharp wave-ripples (SWRs) are population oscillatory patterns in hippocampal LFPs during deep sleep and immobility, involved in the replay of memories acquired during wakefulness. SWRs have been extensively studied, but their exact generation mechanism is still unknown. A computational model has suggested that fast perisomatic inhibition may generate the high frequency ripples (~200 Hz). Another model showed how replay of memories can be controlled by various classes of inhibitory interneurons targeting specific parts of pyramidal cells (PC) and firing at particular SWR phases. Optogenetic studies revealed new roles for interneuronal classes and rich dynamic interplays between them, shedding new light in their potential role in SWRs. Here, we integrate these findings in a conceptual model of how dendritic and somatic inhibition may collectively contribute to the SWR generation. We suggest that sharp wave excitation and basket cell (BC) recurrent inhibition synchronises BC spiking in ripple frequencies. This rhythm is imposed on bistratified cells which prevent pyramidal bursting. Axo-axonic and stratum lacunosum/moleculare interneurons are silenced by inhibitory inputs originating in the medial septum. PCs receiving rippling inhibition in both dendritic and perisomatic areas and excitation in their apical dendrites, exhibit sparse ripple phase-locked spiking. |
format | Online Article Text |
id | pubmed-3644622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36446222013-05-07 Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes Cutsuridis, Vassilis Taxidis, Jiannis Front Syst Neurosci Neuroscience Sharp wave-ripples (SWRs) are population oscillatory patterns in hippocampal LFPs during deep sleep and immobility, involved in the replay of memories acquired during wakefulness. SWRs have been extensively studied, but their exact generation mechanism is still unknown. A computational model has suggested that fast perisomatic inhibition may generate the high frequency ripples (~200 Hz). Another model showed how replay of memories can be controlled by various classes of inhibitory interneurons targeting specific parts of pyramidal cells (PC) and firing at particular SWR phases. Optogenetic studies revealed new roles for interneuronal classes and rich dynamic interplays between them, shedding new light in their potential role in SWRs. Here, we integrate these findings in a conceptual model of how dendritic and somatic inhibition may collectively contribute to the SWR generation. We suggest that sharp wave excitation and basket cell (BC) recurrent inhibition synchronises BC spiking in ripple frequencies. This rhythm is imposed on bistratified cells which prevent pyramidal bursting. Axo-axonic and stratum lacunosum/moleculare interneurons are silenced by inhibitory inputs originating in the medial septum. PCs receiving rippling inhibition in both dendritic and perisomatic areas and excitation in their apical dendrites, exhibit sparse ripple phase-locked spiking. Frontiers Media S.A. 2013-05-06 /pmc/articles/PMC3644622/ /pubmed/23653599 http://dx.doi.org/10.3389/fnsys.2013.00013 Text en Copyright © 2013 Cutsuridis and Taxidis. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Neuroscience Cutsuridis, Vassilis Taxidis, Jiannis Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes |
title | Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes |
title_full | Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes |
title_fullStr | Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes |
title_full_unstemmed | Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes |
title_short | Deciphering the role of CA1 inhibitory circuits in sharp wave-ripple complexes |
title_sort | deciphering the role of ca1 inhibitory circuits in sharp wave-ripple complexes |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644622/ https://www.ncbi.nlm.nih.gov/pubmed/23653599 http://dx.doi.org/10.3389/fnsys.2013.00013 |
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