Need to quickly excrete K(+)? Turn off NCC

Renal K(+) excretion is increased rapidly following dietary K(+) intake, but the underlying molecular mechanisms are largely unknown. Sorensen and colleagues show that K(+) intake in mice provoked rapid and near complete dephosphorylation of the renal distal convoluted tubule NaCl cotransporter, tem...

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Detalles Bibliográficos
Autores principales: McDonough, Alicia A., Youn, Jang H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644996/
https://www.ncbi.nlm.nih.gov/pubmed/23633048
http://dx.doi.org/10.1038/ki.2012.468
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author McDonough, Alicia A.
Youn, Jang H.
author_facet McDonough, Alicia A.
Youn, Jang H.
author_sort McDonough, Alicia A.
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description Renal K(+) excretion is increased rapidly following dietary K(+) intake, but the underlying molecular mechanisms are largely unknown. Sorensen and colleagues show that K(+) intake in mice provoked rapid and near complete dephosphorylation of the renal distal convoluted tubule NaCl cotransporter, temporally associated with increases in both Na(+) and K(+) excretion. This response was independent of aldosterone and may be a crucial component of the acute homeostatic adaptation of the kidney to K(+) intake.
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spelling pubmed-36449962013-11-01 Need to quickly excrete K(+)? Turn off NCC McDonough, Alicia A. Youn, Jang H. Kidney Int Article Renal K(+) excretion is increased rapidly following dietary K(+) intake, but the underlying molecular mechanisms are largely unknown. Sorensen and colleagues show that K(+) intake in mice provoked rapid and near complete dephosphorylation of the renal distal convoluted tubule NaCl cotransporter, temporally associated with increases in both Na(+) and K(+) excretion. This response was independent of aldosterone and may be a crucial component of the acute homeostatic adaptation of the kidney to K(+) intake. 2013-05 /pmc/articles/PMC3644996/ /pubmed/23633048 http://dx.doi.org/10.1038/ki.2012.468 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
McDonough, Alicia A.
Youn, Jang H.
Need to quickly excrete K(+)? Turn off NCC
title Need to quickly excrete K(+)? Turn off NCC
title_full Need to quickly excrete K(+)? Turn off NCC
title_fullStr Need to quickly excrete K(+)? Turn off NCC
title_full_unstemmed Need to quickly excrete K(+)? Turn off NCC
title_short Need to quickly excrete K(+)? Turn off NCC
title_sort need to quickly excrete k(+)? turn off ncc
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644996/
https://www.ncbi.nlm.nih.gov/pubmed/23633048
http://dx.doi.org/10.1038/ki.2012.468
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